The catabolism of Tay-Sachs ganglioside, N-acetylgalactosaminyl- (N-acetylneuraminosyl) -galactosylglucosylceramide, has been studied in lysosomal preparations from normal human brain and brain obtained at biopsy from Tay-Sachs patients. Utilizing Tay-Sachs ganglioside labeled with (14)C in the N-acetylgalactosaminyl portion or (3)H in the N-acetylneuraminosyl portion, the catabolism of Tay-Sac...

In previous work we have studied how an explicit representation of background knowledge associated with a specific spreadsheet can be exploited to alleviate usability problems with spreadsheet-based applications. We have implemented this approach in the SACHS system to provide a semantic help system for spreadsheets applications. In this paper, we evaluate the (comprehension) coverage of SACHS ...

Introduction Posterosuperolateral compression fractures of the humeral head, eponymously described by Hill and Sachs in 1940, occur in 40-90% of anterior shoulder dislocations and typically occur in conjunction with anterior capsulolabral tears (Bankart and variant lesions). Repairing a Bankart lesion without simultaneously addressing significant Hill-Sachs lesions may result in repeated instab...

The nineteenth century witnessed some of the greatest neuroanatomists of all times. Amongst them is the largely forgotten Heinrich Sachs, a student of Carl Wernicke in Breslau. Sachs was a German neurologist, born in 1863 in Halberstadt a town in the German state of Saxony-Anhalt and the capital of the district of Harz. Despite his upbringing in a lower-income background, he was able to study m...

Tay-Sachs disease is a severe, inherited disease of the nervous system caused by accumulation of the brain lipid GM2 ganglioside. Mouse models of Tay-Sachs disease have revealed a metabolic bypass of the genetic defect based on the more potent activity of the enzyme sialidase towards GM2. To determine whether increasing the level of sialidase would produce a similar effect in human Tay-Sachs ce...

CONTEXT Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populatio...

INTRODUCTION Hills-Sachs lesions are commonly associated with anterior shoulder dislocations and can be a source of recurrent instability. Studies have shown that, even after soft tissue repair of a Bankart lesion, there is still a risk for redislocation in a patient with significant bony defects. The purpose of this study is to ascertain whether balloon humeroplasty is an effective technique o...

A consequence of non-Gaussian perturbations on the Sachs-Wolfe effect is studied. For a particular power spectrum, predicted Sachs-Wolfe effects are calculated for two cases: Gaussian (random phase) configuration, and a specific kind of non-Gaussian configuration. We obtain a result that the Sachs-Wolfe effect for the latter case is smaller when each temperature fluctuation is properly normaliz...