al1). Ribosomal protein S19 (RPS19) was identified as a candidate gene for DBA and mutations in this gene have been described in 25% of DBA patients.2,3 However, the mechanism by which mutations in RPS19 can lead to DBA remains unclear. RPS19 is a structural component of a small ribosomal subunit and is known to have two other functions. First, RPS19 homodimers are released by apoptotic cells a...