Introduction Heat shock protein 90 (HSP90) is required for the stability and activity of many proteins, including NEU/HER2 and its downstream proteins, which have key roles in cell growth and survival. Amplification and overexpression of NEU/HER2 proto-oncogene is observed in 25% of human breast cancers (1). 17-AAG is a novel anticancer drug that inhibits HSP90 leading to combinatorial degradat...

Despite increased vector control efforts, dengue fever remains endemic in Fortaleza, Northeast Brazil, where sporadic epidemic outbreaks have occurred since 1986. Multiple factors affect vector ecology such as social policy, migration, urbanization, city water supply, garbage disposal and housing conditions, as well as community level understanding of the disease and related practices. This des...

The nature of forest structure plays an important role in the study of foraging behaviors of bats. In this study, we demonstrate a new combined methodology that uses both thermal imaging technology and a ground-based LiDAR system to record and reconstruct Eptesicus fuscus (big brown bats) flight trajectories in three-dimensional (3-D) space. The combination of the two 3-D datasets provided a fi...

This paper presents a time-multiplexed plasma-etching method for high numerical aperture paraboloidal micromirrors. By designing the appropriate opening and spacing of etching windows, one can fabricate micromirror arrays with varying focal lengths within one batch. INTRODUCTION Curved micromirrors, including various existing deformable micromirrors, e.g. [1-3], have many applications in micro-...

The use of GdIII complexes as contrast agents in magnetic resonance imaging (MRI) has proven invaluable in the diagnosis of several internal abnormalities.1 The range of medical applications for which contrast agents are useful is likely to increase in the future with the development of target-specific contrast agents of increased relaxivity, such as MS-325 which binds with HSA in the blood poo...

Pharmacokinetically tailored insulin has been rationally designed by molecular structural engineering and/or pharmaceutical formulation to improve glucose control and convenience for people with diabetes.Novel mechanisms protracted action based on reduced plasma clearance hold promise enable once-weekly subcutaneous once-daily oral basal delivery.Hepato-preferential analogs can be tailoring siz...

•Sleep medicine is cataloged according to a conventional disease classification system. Disease models are rooted in the pathophysiology of sleep. Polysomnography and other tests used demonstrate pathophysiological mechanisms underlying currently known sleep disorders.•Although many patients with disorders may be adequately managed by this approach, therapeutic results insufficient some subject...

Influenza vaccine efficacy is reduced among adults over age 65 and a significant number of vaccinated elderly may remain susceptible to influenza virus infection. The effect of moderate exercise training on the immune response to influenza immunization was evaluated in this study. Twenty-seven adults >or=age 64 were assigned to an exercise group (n= 14) or a control group (n = 13). The subjects...

While any improvement in wealth and consumption will likely increase happiness, the increased happiness may or may not last long. In this article we offer two recommendations to make the increased happiness sustainable. The first one—to invest resources to promote adaptationresistant rather than adaptation-prone consumption—seeks to make the increased happiness sustainable within a generation. ...

Objectives: This study aimed at designing and assessing educational materials for adult immunizations through the medium of comics. The study design evaluated the effects of two vaccine information flyers (a CDC flyer vs a flyer designed in Comic medium) on participants’ attitude towards the flyers. Methods: A between-group, randomized trial was used to compare the effectiveness of two vaccine ...