Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. They are most commonly observed in the oral cavity, skin and subcutaneous tissue, breast, and respirat...

The Receptor for Advanced Glycation Endproducts (RAGE) has been suggested to play an important role in melanoma. Animal studies with anti-RAGE antibodies have shown that RAGE blockade leads to reduced melanoma tumor growth and metastasis formation. RAGE is a multiligand receptor and among its ligands are the Ca-binding S100 proteins. Certain S100 proteins are differentially expressed in melanom...

this report describes the histological and immunohistochemical features of a small intestinal tumor that resembled a human gastrointestinal stromal tumor (gists) in a seven-year-old male cross-breed dog. this was unique because of the expression of desmin by the tumor. grossly, the white-gray tumor measured 8.0 × 4.0 × 6.5 cm and was 760 gram in weight. it was cystic and enveloped the jejunum. ...

OBJECTIVE The aim of this study was to determine the expression of S100 positive dendritic cells (DCs) and the relationship with clinicopathologic factors in endometrial carcinoma. METHODS Samples were collected from 89 patients with endometrial endometrioid adenocarcinoma treated in Pusan National University Hospital from 2004 to 2011. Normal endometrial tissues were obtained from 30 hystere...

Tumors of the ear with neuroendocrine features are a very rare group neoplasms, adenoma representing more frequent entity found; prevalence middle tumors is so low that it has never been determined exactly. Herein we describe case 74 years old woman who presented pure moderately differentiated tumor after long history adhesive otitis media. Patient abruptly developed otalgia and sense plugged e...

S100-positive T lymphocytes account for less than 3% of peripheral blood T cells. Rare cases of S100-positive T-cell lymphoma have been previously described. We report four such cases of S100-positive T-cell chronic lymphoproliferative disease. In all cases, hepatosplenomegaly was observed, without prominent lymphadenopathy. Central nervous system (CNS) involvement by the leukemic cells was sug...

CONTEXT Clinical and experimental studies have suggested a link between S100 gene ex-pression and neoplastic disorders, however, the molecular mechanisms of this associa-tion are not well understood. The aim of this review was to conduct a comprehensive literature search in order to understand the possible underlying molecular mechanisms of this association. We also discuss their application as...

Background: Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are defined as malignant tumors arising from a peripheral nerve or displaying sheath differentiation. We report the first Korean case of MPNST ileum. Case Presentation: A 33-year-old female without family history neurofibromatosis type I complained lower abdominal pain. An abdomen computed tomography and enhanced magnetic resonance i...

  Myoepitheliomas are benign tumors which account for less than 1% of all salivary gland tumors. In this article, we report the clinical, pathologic, and immunohistochemical features of plasmacytoid myoepithelioma of the hard palate in a 73-year-old man having a painless hard palate mass with progressiv...