the leukocyte mi gration test (lht) in the prese nce of na t i v e igg, and l l e v amis ole were studi ed in 9 patients su f f e ring from cla s s i c a l r h e umatoid ar.thri t i s be f o r e a nd after treatment with l evamisole . fi f teen heal thy b l o od dono rs we r e s i mi l a r ly l nvestig ated a s cont r o ls . t- l ympho c yte s ub-popu lations (to ta l a nd active) a nd b-c el l...

we have previously shown that the proliferative response of t cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (cr) attenuated the age-related decline in proliferation and il-2 expression. because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...

background: chronic inflammation and dys-regulation of the immune system mechanisms are now well established as primary triggers of gastric cancer and peptic ulcer disease. galectin-9 (gal-9) is a member of the galectin family and known as an inducer of cell aggregation, adhesion and apoptosis. gal-9 interaction with its main ligand t-cell immunoglobulin and mucin domain protein-3 (tim-3) leads...

objective: in an attempt to develop safer and more effective gene therapy approaches as a realistic treatment for various forms of cancer, researchers are increasingly using tumor-specific promoters (tsp) to drive the expression of the gene of interest and eradicate cancer cells. in this study, for the first time we introduce the oct-4 promoter as a cancer-specific promoter with a high efficacy...

cold stress is considered as a restricting factor in plant production. recently, many different compounds were applied to minimize the harmful effects of stress. in this study, the effects of foliar application of salicylic acid was studied on some biochemical properties of two different cold resistant canola cultivars. salicylic acid was sprayed at four concentrations (0, 100, 200 and 400 µm) ...

silica sulfuric acid is found to catalyze efficiently the condensation of o-phenylenediamines with various linear and cyclic ketones to afford the corresponding 1,5-benzodiazepines in quantitative yields under solvent-free conditions at room temperature

background: human cripto-1, a member of the egf-cfc family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. it also participates in multiple cell signaling pathways including wnt, notch, and tgf-β. remarkably, it is expressed in cancer stem cell (csc) compartments, boosting tumor cell migration, invasion, and angiogenesis. although cripto-1 is overe...

tetrahydrobenzo[b]pyran derivatives 1 were utilized for the synthesis of several new pyrano[2,3-d]pyrimidine derivatives 2. compound 2 was obtained in the presence of ac2o/h2so4 (as a catalyst) and was confirmed by spectroscopic data such as ir, 1h nmr and 13c nmr. ab initio calculation was carried out to study geometric optimization, thermodynamic parameters, aromaticity and dynamic process of...