chemokines and their receptors  play an important  role in the  late inflammatory stage of asthma. in this study, we aimed to investigate polymorphisms of mcp-1 (ccl2), ccr2 and ccr5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features. mcp-1   (a/g   -2518),  ccr2   (+/64i), ...

results at high concentrations (40 and 100 μm), apoptosis was demonstrated and it was clearly more prominent in hepatocytes exposed to celecoxib loaded liposomes. conclusions our results showed that celecoxib loaded liposomes robustly induced apoptosis, an action that can potentially make it more relevant than the usual form for chemopreventive strategies and also may raise concerns about its t...

conclusions according to the results, the polymorphisms within the +49 position of ctla-4 can be associated with vl and may be considered as risk factors for the disease. results our results indicated that both ctla-4 +49a/g polymorphisms were significantly associated with vl. materials and methods in this cross-sectional study, 88 patients with clinical presentations of vl, who were seropositi...

staphylococcus aureus is a major causative pathogen of clinical and subclinical mastitis of dairy domestic ruminants. this agent produces a variety of extracellular toxins and virulence factors including toxic shock syndrome toxin-1 (tsst-1) which is the major cause of toxic shock syndrome (tss). in this study 58 s. aureus isolates obtained from 9 dairy herds in east and west azerbaijan prov...

objective(s):one of the major challenges in the field of vaccine design is choosing immunogenic antigens which can induce a proper immune response against complex targets like malignant cells or recondite diseases caused by protozoan parasites such as leishmaniasis. the aim of this study was to find a way to construct artificial liposome-based cells containing fragments of target’s cell membran...

conclusions vaccine based on the conjugation of p. aeruginosa pao-1 lps with dt increased anti-lps antibodies and had a significant potential to protect against pseudomonas infections. background treatment of pseudomonas aeruginosa pao-1 infections through immunological means has been proved to be efficient and protective. objectives the purpose of this study was to produce a conjugate vaccine ...

background phytotherapy is a popular treatment option in cases of benign prostatic hyperplasia (bph), with many different herbal products being used for the treatment of this condition. withania coagulans (wc) is an herbal medicine that has shown anti-tumoral, anti-inflammatory, and antioxidant effects. objectives this study examined the effect of withania coagulans extract (wce) on prostatic c...

background: prostate specific antigen (psa) has been used as a screening test for the early detection of prostate cancer (pc) for many years. although the introduction of psa test led to a considerable increase in reported prostate cancer cases, there is still some controversy over the sensitivity and specificity of this marker in distinguishing pc patients from those with benign prostate hyper...

many species belonging to the scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. the aim of this study was to characterize the matrix metalloproteinases (mmps) inhibitor compounds of the scrophularia striata extract by bio-guide fractionation. the aerial parts of s. striata were...