Aqueous, ethanolic and methanolic extracts of Ruta graveolens were investigated for anti-inflammatory activity in carrageenan induced paw edema in wistar male rats, and compared to a positive control drug, Voveran. These extracts were given (ip) in a concentration of 20 and 50 mg/kg b.w. before carrageenan injection. Methanolic extracts of R. graveolens with a concentration of 20 mg/kg b.w. and...

The biosynthesis of some furocoumarins present in Ruta graveolens has been studied administering labeled psoralen, xanthotoxin, rutaretin, marmesin and 7-hydroxycoumarin-derivatives. The results obtained indicate that the biosynthetic pathway involves not only psoralen, but also xanthotoxin and bergapten, by means of methoxylation or demethoxylation reactions. Moreover results achieved from adm...

Acridone synthase has been purified from cell suspension cultures of Ruta graveolens using a combination of gel filtration and ion exchange chromatography. The purified enzyme has an apparent molecular weight of 69 kDa on gel filtration and a subunit structure on SDS-PAGE of 40 kDa. The apparent Km-values are 10.64 microM and 32.8 microM for N-methylanthraniloyl-CoA and malonyl-CoA, respectivel...

Antimicrobial screening against selected Gram-positive and Gram-negative bacteria, yeasts, mold, as well as plant pathogenic fungi, with emphasis on method optimization was carried out on methanol extracts prepared from seven plants grown in Finland. Sensitivity to the extracts was found to vary considerably among the micro-organisms, the extract from Petroselinum crispum and Ruta graveolens sh...

A young lady applied herbal mask of common rue (Ruta graveolens) onto her face. After that, she took a nap on a balcony in the full sun. An hour later, she woke up with a burning sensation, erythema and oedema of the skin. A few hours later, painful erythema and oedema developed. Subsequently, she developed a bullous reaction, which became superinfected in the following days. After treatment of...

DNA ADDUCT BYPASS POLYMERIZATION BY SULFOLOBUS solfataricus DNA POLYMERASE DPO4 ANALYSIS AND CRYSTAL STRUCTURES OF MULTIPLE BASE-PAIR SUBSTITUTION AND FRAMESHIFT PRODUCTS WITH THE ADDUCT 1,N-ETHENOGUANINE Hong Zang‡, Angela K. Goodenough§¶, Jeong-Yun Choi‡, Adriana Irimia, Lioudmila V. Loukachevitch, Ivan D. Kozekov§, Karen C. Angel‡, Carmelo J. Rizzo§, Martin Egli‡, and F. Peter Guengerich‡** ...

Heterotrophic cell suspension cultures of Ruta graveolens were established by reversion of photom ixotrophic cultures without any change in the chemical composition of the growth medium. The heterotrophic cultures were qualitatively and quantitatively analyzed by gaschromatography and mass spectroscopy for volatile compounds. The terpenoid hydrocarbons geijerene and pregeijerene, C6-C8 ketones,...