Rubinste in-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes as well as mental and statural deficiencies. RTS has a prevalence of 1 in 330,000 births and usually occurs sporadically, although it can be inherited as an autosomal dominant disorder. The diagnosis is based on characteristic features. The main clinical symptoms a...

BACKGROUND To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals). METHODS In a double-blind, randomized trial, 102 healthy volunteers were evenly allocated to receive RTS,S/AS01B or RTS,S/AS02A vaccine at months 0, 1, and 2 of the study, followed by malaria challenge. Protected vacc...

Abstract This paper analyses the human right to science (RtS) in relation data (DS) and its applications, particularly, monetization. It advances an approach that balances three aspects of RtS, namely, protection from harmful science, benefit-sharing participation derives corresponding sets state duties. First, RtS implies duty end monetization so far as it entails practices rights, including u...

Much less is known about reverse transcriptases (RTs) in prokaryotes than in eukaryotes, with most prokaryotic enzymes still uncharacterized. Two surveys involving BLAST searches for RT genes in prokaryotic genomes revealed the presence of large numbers of diverse, uncharacterized RTs and RT-like sequences. Here, using consistent annotation across all sequenced bacterial species from GenBank an...

Tento článek je zaměřen na oceňování s využitím BIM, tedy informačního modelu budovy. Cílem tohoto článku ocenit stavbu nákladovým způsobem pomocí BIM modelu. Obsahem popis problematiky, dále její zavádění a potřeba využití ve stavebnictví. Článek popisuje metody ocenění názorně zobrazuje vybrané konstrukce jednotlivými metodami. Hlavní oceňovací metodou plugin RTS který využívá model vytvořený...

—Three infectious pancreatic necrosis virus (IPNV) isolates (A1 serotype, Buhl subtype) were passaged five times in rainbow trout gonad (RTG)-2 cells with either minimum essential medium supplemented with 10% fetal bovine serum (MEM-10) or MEM-10 supplemented with 1% rainbow trout Oncorhynchus mykiss serum (MEM2RTS) to determine the effect of passage of the virus on its virulence and sensitivit...

Syndrome specific repetitive behavior profiles have been described previously. A detailed profile is absent for Rubinstein-Taybi syndrome (RTS). The Repetitive Behaviour Questionnaire and Social Communication Questionnaire were completed for children and adults with RTS (N = 87), Fragile-X (N = 196) and Down (N = 132) syndromes, and individuals reaching cut-off for autism spectrum disorder (N =...

OBJECTIVE RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis B surface antigen in a hybrid protein. The RTS,S antigen is formulated with GSK Biologicals' proprietary Adjuvant Systems AS02(A) or AS01(B). A recent trial of the RTS,S/AS02(A)...