نتایج جستجو برای: rtk
تعداد نتایج: 2049 فیلتر نتایج به سال:
GNSS community has developed a series of GPS-based techniques for clock measurements and comparisons including time dissemination with the standard GPS point positioning method, clock synchronization using the codebased differential GPS positioning technique and using precise point positioning (PPP) for clock comparison. In the mean time, significant advances have been made towards real time ki...
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenance of drug resistance in RTK-driven cancer. Using fibroblast growth factor receptor (FGFR) inhibition in endometrial cancer cells, we identify an Akt-driven...
امروزه کاربرد سیستم تعیین موقعیت gps به منظور محاسبه تعیین وضعیت یک سکوی متحرک رایج شده است. به همین منظور، موقعیت نسبی آنتنهای gps با استفاده از اندازهگیری های کد و یا فاز محاسبه و مورد استفاده قرار میگیرد. سپس پارامترهای وضعیت از مختصات محاسبه شده استخراج میگردد. در این مقاله مشاهدات فاز چهار گیرنده تک فرکانسه gps مورد استفاده قرار گرفته است تا وضعیت سکو محاسبه شود. همچنین به منظور برآور...
A limited number of whole-cell assays allow monitoring of receptor tyrosine kinase (RTK) activity in a signaling pathway-specific manner. We present the general use of the bioluminescence resonance energy transfer (BRET) technology to quantitatively study the pharmacology and signaling properties of the receptor tyrosine kinase (RTK) superfamily. RTK BRET-2 assays monitor, in living cells, the ...
The induction of protein tyrosine kinase signaling pathways is a principal mechanism for promoting cellular activation. Biochemical and genetic analyses have implicated the multi-adaptor proto-oncogene protein Cbl as a key negative regulator of activated protein tyrosine kinases. By inhibiting the function of Cbl as a multi-domain adaptor protein, through expression of a truncated form (480-Cbl...
Pulmonary vascular dilation and angiogenesis underlie experimental hepatopulmonary syndrome (HPS) induced by common bile duct ligation (CBDL) and may respond to receptor tyrosine kinase (RTK) inhibition. Vascular endothelial growth factor-A (VEGF-A) expression occurs in proliferating cholangiocytes and pulmonary intravascular monocytes after CBDL, the latter contributing to angiogenesis. CBDL c...
In this contribution, a novel un-differenced (UD) (PPP-RTK) concept, i.e. a synthesis of Precise Point Positioning and Network-based Real-Time Kinematic concept, is introduced. In the first step of our PPP-RTK approach, the UD GNSS observations from a regional reference network are processed based upon re-parameterised observation equations, corrections for satellite clocks, phase biases and (i...
Lately, unmanned aerial vehicles (UAV) evolve into one of the most popular remote sensing technologies by providing rapid and periodical acquisition high-resolution, accurate, low-cost data. Progressively, technology UAVs rises with addition advanced equipment such as multispectral (MS) digital cameras global navigation satellite system (GNSS) receivers real-time time kinematic (RTK) positionin...
Trophic factors control cellular physiology by activating specific receptor tyrosine kinases (RTKs). While the over activation of RTK signaling pathways is associated with cell growth and cancer, recent findings support the concept that impaired down-regulation or deactivation of RTKs may also be a mechanism involved in tumor formation. Under this perspective, the molecular determinants of RTK ...
Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling pathways control many aspects of C. elegans development and behavior. Studies in C. elegans helped elucidate the basic framework of the RTK-Ras-ERK pathway and continue to provide insights into its complex regulation, its biological roles, how it elicits cell-type appropriate responses, and how it interacts...
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