Introduction: Autoimmune hepatitis (AIH) is one of autoimmune disorder with complex pathophysiology. Many genes involved in lethal including STAT4 gene. The aim this study to determine gene polymorphisms and relation SNPs disease severity among AIH patients. Method: One hundred patient which diagnosed by clinically, ANA ASMA 100 control age matched healthy children were enrolled study. Patients...

Background: Psoriatic arthritis (PsA) is a chronic inflammatory joint disease typically associated with psoriasis and classified in the group of spondyloarthritis (1). The pathogenesis based on an interplay different genes interacting several environmental factors including stress, trauma, infections, triggering response related to activation innate acquired immunity tissues organs (2). However...

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with significant genetic predisposition. Recent studies have identified STAT4 (signal transducers and transcription activators 4) as susceptibility gene for SLE. Objectives: To investigate the hypothesis of association rs7574865 G/T polymorphism predisposition to SLE in children its relationship some manifestations. ...