In-stent restenosis (ISR) is recently challenging complication of coronary stent implantation in both stable coronary artery disease (CAD) and acute coronary syndrome (ACS). Since coronaroplasty is not only done using balloons, the stent era has pushed invasive cardiology further also to the new era of procedures’ complications, including drawback due to ISR [1]. Single nucleotide polymorphism ...

Endothelial Nitric Oxide Synthase Polymorphism rs3918226 Associated With Hypertension Does Not Affect Plasma Nitrite Levels in Healthy Subjects To the Editor: Salvi et al reported that the single nucleotide polymorphism (SNP) rs3918226 in the promoter of the endothelial NO synthase (eNOS) gene was associated with hypertension. Although no functional studies show how this SNP affects eNOS, the a...

PURPOSE Bacillus Calmette-Guérin (BCG)-treatment is an established treatment for bladder cancer, but its mechanisms of action are not fully understood. High-risk non-muscle invasive bladder-cancer (NMIBC)-patients failing to respond to BCG-treatment have worse prognosis than those undergoing immediate radical cystectomy and identification of patients at risk for BCG-failure is of high priority....

Relevance – it is promising to develop a system for the diagnosis and prevention of primary open-angle glaucoma (POAG), which would be based on determination constitutive propensity factors able predict onset progression disease. The aim study was model predicting rate depending gender endothelial NO-synthase (NOS3) gene polymorphism. There were genotyped 153 patients with POAG aged 36-84 years...

BACKGROUND Oxidative stress genes are related to cancer development and treatment response. In this study, we aimed to determine the predictive and prognostic roles of oxidative stress-related genetic polymorphisms in metastatic gastric cancer (MGC) patients treated with chemotherapy. METHODS In this retrospective study, we genotyped nine oxidative stress-related single nucleotide polymorphis...

Chronic mountain sickness (CMS) is estimated at 1.2% in Tibetans living at the Qinghai-Tibetan Plateau. Eighteen single-nucleotide polymorphisms (SNPs) from nine nuclear genes that have an association with CMS in Tibetans have been analyzed by using pairwise linkage disequilibrium (LD). The SNPs included are the angiotensin-converting enzyme (rs4340), the angiotensinogen (rs699), and the angiot...

Endothelial NOS (NOS3) has a potential role in the prevention of neuronal injury in hypoxic-ischemic encephalopathy (HIE). Thus, we aimed to explore the association between NOS3 gene polymorphisms and HIE susceptibility and symptoms in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) in the NOS3 gene, rs1800783, rs1800779, and rs2070744, were detected in 226 children with ...

Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Polymorphisms in the eNOS gene have been found to be associated with hypertension in different human populations, including Northern and Southern Chinese Han populations. To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (...

BACKGROUND Atherosclerosis is a complex multifocal arterial disease involving interactions between multiple genetic and environmental factors. OBJECTIVES In the present study, we investigated the possible association between NOS3 (rs1799983), MTHFR (rs1801133), APOB (rs5742904) and TNF-α (rs361525) polymorphisms and the risk of coronary atherosclerotic lesions in Iranian patients. PATIENTS ...