To determine the effects of ingested royal jelly (RJ) on the pituitary in middle-aged female rats, we performed a long-term RJ administration test. Several animals showed age-related increases in pituitary weight, and RJ administration compensated for the increase. RJ tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone beta mRNA in the pituitary. This suggests th...

Background: Chronic diabetes mellitus is accompanied with enhanced oxidative stress and reduce the activity of antioxidant defense system. Due to significant role of enhanced oxidative stress in development of testes damage in diabetices, this study was conducted to evaluate the effect of royal jelly on oxidative stress marker in testis tissue of diabetic rats. Materials and Methods: In this ex...

Unbiased symmetric metrics to quantify the relative bias and error between modeled and observed concentrations, based on the factor between measured and observed concentrations, are introduced and compared to conventionally employed metrics. Application to the evaluation of several data sets shows that the new metrics overcome concerns with the conventional metrics and provide useful measures o...

Objective(s):Paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. The cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages. Materials and Methods:Adult male Wistar rats were divided into control and te...

Objectives: Royal jelly (RJ), a secretion of both the hypopharyngeal and mandibular glands of nurse workers, is believed to play a central role in honeybee queen development. Important component of royal jelly are proteins which form about 50% of the dry mass of RJ. Major royal jelly proteins (MRJPs) are the dominant proteinaceous component of royal jelly and constitute about 82-90% of total pr...

Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats. Materials and Methods: For diabetes in...

Background: Phenylhydrazine (PHZ) is used to induce experimental anemia in animal models. On the other hand royal jelly is known as antioxidant compound. Therefore, here in present study we aimed to evaluate the protective effect of royal jelly on PHZ-induced damages in testicular tissue and compare its impact with vitamin C. Materials and Methods: Eighteen mature male mice were randomly divide...

background royal jelly (rj), a food item secreted by worker honeybees, is a mixture that contains protein, glucose, lipid, vitamins, and minerals; it is widely used as a commercial medical product. previous studies have shown that rj has a number of physiological effects, such as anti-inflammatory, antitumor, antiallergic and antioxidant activities. objectives in the present study, the anti-inf...

conclusions it seems that rj does not appear to have significant immediate effects on glycemic factors in patients with type 2 diabetes. however, further studies with larger sample sizes and different doses of rj are needed to achieve more precise results. background type 2 diabetes is the fourth major public health problem worldwide. royal jelly (rj) insulin-like activity and blood glucose mod...