Three years after the withdrawal of fenfluramine and dexfenfluramine from the market, the magnitude and prevalence of their deleterious cardiopulmonary effects remain undetermined. The links between these anorexigens and valvular heart disease and primary pulmonary hypertension, however, are clearly established. Because some evidence indicates that the valvular lesions may regress with cessatio...

Wereadwithgreat interest thecase reportof fatalpoisoningsdue to snorting buprenorphine (BUP) combined with alcohol consumption by Ferrant et al. [1]. As explained by the authors, snorting of crushed BUP tablets is common in drug addicts under maintenance treatment and may result in fatal poisonings. We recently reported thirty-nine acute poisonings with typical life-threatening opioid syndrome ...

We report the case of a 52-year-old woman with advanced colorectal cancer who was treated with oxaliplatin on a FOLFOX schedule. After 3 cycles of chemotherapy, she started to complain of visual loss, altered color vision and neurological symptoms. Due to the suspicion of ocular and neurological toxicity, antineoplastic treatment was stopped. Her visual field showed a concentric bilateral scoto...

yperlipidemia is widely recognized as one of the major risk factors for coronary heart disease (CHD). Whereas therapeutic lifestyle changes are the first-line modality for reducing low-density lipoprotein (LDL) cholesterol, many patients also require medication to achieve cholesterol level goals. Primary and secondary prevention studies have demonstrated that adequate reduction of LDL cholester...

The oral route for drug delivery is regarded as the optimal route for achieving therapeutic benefits owing to increased patient compliance. Despite phenomenal advances in injectable, transdermal, nasal and other routes of administration, the reality is that oral drug delivery remains well ahead of the pack as the preferred delivery route. Nanocarriers can overcome the major challenges associate...

Objective: Zayandehrood habitat has economical and environmental importance in central plateau of Iran    and it performs a vital role for habitants, agriculture section and the industries which are located along river bed. So current research  has been done to measure the contamination of heavy metals, its changes along the river route and defining the important and effective regions on this c...