نتایج جستجو برای: rnase

تعداد نتایج: 8269  

Journal: :Nucleic acids research 2003
Jianzhi Zhang Kimberly D Dyer Helene F Rosenberg

Here we report on the expression and function of RNase 7, one of the final RNase A superfamily ribonucleases identified in the human genome sequence. The human RNase 7 gene is expressed in various somatic tissues including the liver, kidney, skeletal muscle and heart. Recombinant RNase 7 is ribonucleolytically active against yeast tRNA, as expected from the presence of eight conserved cysteines...

2015
Brian Becknell Tad Eichler Susana Beceiro Birong Li Robert Easterling Ashley R. Carpenter Cindy James Kirk M. McHugh David S. Hains Santiago Partida-Sanchez John David Spencer

Recent evidence suggests antimicrobial peptides protect the urinary tract from infection. Ribonuclease 7 (RNase 7), a member of the RNase A superfamily, is a potent epithelial-derived protein that maintains human urinary tract sterility. RNase 7 expression is restricted to primates, limiting evaluation of its antimicrobial activity in vivo. Here we identified ribonuclease 6 (RNase 6) as the RNa...

2013
Olga Esakova Anna Perederina Igor Berezin Andrey S. Krasilnikov

Ribonuclease (RNase) MRP is a ubiquitous and essential site-specific eukaryotic endoribonuclease involved in the metabolism of a wide range of RNA molecules. RNase MRP is a ribonucleoprotein with a large catalytic RNA moiety that is closely related to the RNA component of RNase P, and multiple proteins, most of which are shared with RNase P. Here, we report the results of an ultraviolet-cross-l...

Journal: :Nucleic acids research 2004
Naoto Ohtani Hiroshi Yanagawa Masaru Tomita Mitsuhiro Itaya

ST0753, the orthologous gene of Type 1 RNase H found in a thermoacidophilic archaeon, Sulfolobus tokodaii, was analyzed. The recombinant ST0753 protein exhibited RNase H activity in both in vivo and in vitro assays. The protein expressed in an RNase H-deficient mutant Escherichia coli strain functioned to suppress the temperature-sensitive phenotype associated with the lack of RNase H. The in v...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده علوم 1390

سورفکـتانت های دوقلوی کاتیونی دارای دوسر قطـبی و دو دنباله ی هیدروکربنـی می باشند. در مقایسـه با سورفکـتانت های منـومری, سورفکـتانت های دو قلـو دارای غلظت بحرانی میـسل شدن (cmc) پاییـن (میکرومولار در مقابل میلی مولار) بوده, لذا دارای سرعت سینـتیکی پایین تر تبدیل منومر ??میـسل (میلی ثانیه در مقابل میکروثانیه) می باشند. ساختار کلی سورفکـتانت های دوقلوی کاتـیونی آلکان دی ایل- ?, ?- بیـس (هیدروکسی ...

Journal: :The Journal of biological chemistry 2014
Chelcie H Eller Jo E Lomax Ronald T Raines

Mounting evidence suggests that human pancreatic ribonuclease (RNase 1) plays important roles in vivo, ranging from regulating blood clotting and inflammation to directly counteracting tumorigenic cells. Understanding these putative roles has been pursued with continual comparisons of human RNase 1 to bovine RNase A, an enzyme that appears to function primarily in the ruminant gut. Our results ...

2009
Bente Köten Maren Simanski Regine Gläser Rainer Podschun Jens-Michael Schröder Jürgen Harder

BACKGROUND Human skin is able to mount a fast response against invading microorganisms by the release of antimicrobial proteins such as the ribonuclease RNase 7. Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was to further explore the role of RNase 7 in the cutaneous innate defense system against E. faecium. METHODOLOGY/PRINCIPAL FINDINGS Absolute q...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Daniel J Coughlin Jeffrey A Pleiss Scott C Walker Gregg B Whitworth David R Engelke

Ribonuclease P (RNase P) is an essential endonuclease responsible for the 5'-end maturation of precursor tRNAs. Bacterial RNase P also processes precursor 4.5S RNA, tmRNA, 30S preribosomal RNA, and several reported protein-coding RNAs. Eukaryotic nuclear RNase P is far more complex than in the bacterial form, employing multiple essential protein subunits in addition to the catalytic RNA subunit...

Journal: :International journal of systematic and evolutionary microbiology 2004
Margaret K Butler John A Fuerst

The planctomycetes, order Planctomycetales, are a distinct phylum of domain Bacteria. Genes encoding the RNA portion of ribonuclease P (RNase P) of some planctomycete members were sequenced and compared with existing database planctomycete sequences. rnpB gene sequences encoding RNase P RNA were generated by a conserved primer PCR strategy for Planctomyces brasiliensis, Planctomyces limnophilus...

Journal: :Genes & development 2012
Bernard Gutmann Anthony Gobert Philippe Giegé

RNase P is an essential enzyme that cleaves the 5' leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity. Here we find that protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support RNase P activity in vivo in both organelles and the nucleus in Arabidopsis. Beyond tRNA, PRORP p...

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