Burkitt lymphoma (BL) is a highly malignant non-Hodgkin's lymphoma that is closely related to the abnormal expression of genes. Familial acute myelogenous leukemia related factor (FAMLF; GenBank accession No. EF413001.1) is a novel gene that was cloned by our research group, and miR-181b is located in the intron of the FAMLF gene. To verify the role of miR-181b and FAMLF in BL, RNAhybrid softwa...

BACKGROUND MicroRNAs are small noncoding RNAs that play critical roles in regulation of gene expression in wide array of tissues including the ovary through sequence complementarity at post-transcriptional level. Tight regulation of multitude of genes involved in ovarian development and folliculogenesis could be regulated at transcription level by these miRNAs. Therefore, tissue specific miRNAs...

BACKGROUND MicroRNAs (miRNAs) have been shown to play a critical role in the development and progression of nasopharyngeal carcinoma (NPC). Although accumulating studies have been performed on the molecular mechanisms of NPC, the miRNA regulatory networks in cancer progression remain largely unknown. Laser capture microdissection (LCM) and deep sequencing are powerful tools that can help us to ...

BACKGROUND Age-related cataracts are related to oxidative stress. However, the genome-wide screening of cataract related oxidative stress related genes are not thoroughly investigated. Our study aims to identify cataract regulated miRNA target genes that are related to oxidative stress and to propose a new possible mechanism for cataract formation. METHODS Microarrays were used to determine t...

Background: Endothelial cell (EC) maladaptation to disturbed blood flow at predilection sites of atherosclerosis is characterized by inflammation and defective regeneration. The RNase Dicer is essential for the production of microRNAs, which play a crucial role in EC maladaptation. EC-derived Dicer promotes atherosclerosis and suppresses KLF4, Notch1, and Wnt signaling. While Dicer increases EC...

Background: MicroRNAs (miRNAs) are small regulatory RNA that mediate RNA interference by binding to various mRNA target regions. There have been several computational methods for the identification of target mRNAs for miRNAs. However, these have considered all contributory features as scalar representations, primarily, as thermodynamic or sequence-based features. Further, a majority of these me...

•Dynamic subgenome landscapes of SARS-CoV-2 in two host cells are constructed•Bidirectional and successive template switching diversify sgRNA biogenesis•Several key determinants governing efficacy discovered•Canonical TRS-independent RNA-RNA interaction mediates switches Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a g...