نتایج جستجو برای: rimmed steel

تعداد نتایج: 81648  

Journal: :Baylor University Medical Center Proceedings 2005

2014
Stefen Brady Waney Squier Caroline Sewry Michael Hanna David Hilton-Jones Janice L Holton

OBJECTIVE The current pathological diagnostic criteria for sporadic inclusion body myositis (IBM) lack sensitivity. Using immunohistochemical techniques abnormal protein aggregates have been identified in IBM, including some associated with neurodegenerative disorders. Our objective was to investigate the diagnostic utility of a number of markers of protein aggregates together with mitochondria...

Journal: :Internal medicine 1998
T Kumamoto S Fujimoto S Nagao T Masuda R Sugihara H Ueyama T Tsuda

In a previous report we suggested that muscle fibers in distal myopathy with rimmed vacuoles (DMRV) were degraded by both lysosomal proteolysis (cathepsins) and Ca2+-dependent, nonlysosomal proteolysis (calpain). Given recent evidence of abnormal ubiquitin accumulation in rimmed vacuoles, we examined the role of the ATP-ubiquitin-dependent proteolytic pathway (proteasomes) in myofiber degradati...

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