The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wall stress since this is the main determinant of changes to the ventricle. Seco...

Whilst failure of the left ventricle (LV) has been the subject of intense interest for decades, failure of the right ventricle (RV) has tended to receive scant attention. Indeed, the RV was long considered a relatively passive conduit for blood flow between the systemic and pulmonary circulations. More recently, the importance of the RV in maintaining haemodynamic stability and organ function h...

The present study examined the antioxidant defense of glutamine on plasma and liver antioxidant status in broilers under PHS with respect to changes in the levels of lipid peroxidation marker malondialdehyde (MDA), total antioxidant status (TAS) and the activities of anti peroxidative enzymes [superoxide dismutase (SOD) and glutathione dependent antioxidant enzymes glutathione peroxidase (GPX)]...

Background Left heart failure is characterized by alterations in metabolic substrate utilization, and metabolic modulation may be a future strategy in the management of heart failure (HF). There is little known about cardiac metabolism in the right ventricle and how it relates to other measures of right ventricular function. This study was designed to measure glucose metabolism in the right ven...

In 1616, Sir William Harvey was the first to describe the importance of right ventricular (RV) function in his seminal treatise, De Motu Cordis: “Thus the right ventricle may be said to be made for the sake of transmitting blood through the lungs, not for nourishing them.”1,2 For many years that followed, emphasis in cardiology was placed on left ventricular (LV) physiology, overshadowing the s...

background thrombolytic therapy in patients with sub-massive pulmonary embolism (smpte) needs further assessment. objectives the current study aimed to assess a potential benefit of thrombolytic and non-thrombolytic therapy in patients with smpte. patients and methods one hundred-nineteen patients were enrolled with smpte from 2006 to 2010 in the tertiary care center of rajaie medical and resea...

Introduction: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (Nox2) is one of the predominant sources of ROS production during myocardial ischemia-reperfusion and can be induced by angiotensin II. The evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. The mechanism...

Acute right coronary artery occlusion proximal to the right ventricular (RV) branches results in right ventricular free wall dysfunction, exerting mechanically disadvantageous effects on biventricular performance. Depressed RV systolic function decreases transpulmonary delivery of left ventricular (LV) preload, resulting in diminished cardiac output. The ischemic right ventricle is stiff, dilat...

Introduction Impaired right ventricle (RV) function is associated with worse outcome in ARDS. Pulmonary artery pressure waveform analysis provides information about phenomena that affect RV performance. In particular, pulmonary vascular wave reflection (WR) is directly related with RV stress. We hypothesised that open lung ventilation (OLV), compared with conventional ARDS-net ventilation (CV),...

assessment of cardiac right‑ventricle functions plays an essential role in diagnosis of arrhythmogenic right ventricular dysplasia (arvd). among clinical tests, cardiac magnetic resonance imaging (mri) is now becoming the most valid imaging technique to diagnose arvd. fatty infiltration of the right ventricular free wall can be visible on cardiac mri. finding right‑ventricle functional paramete...