Specific isoforms of the cAMP-dependent protein kinase are preferentially expressed within discrete neuronal regions in mouse brain (Cadd and McKnight (1989) Neuron 3, 71-79) suggesting that these subunits might have different functional properties. We have used recombinant techniques to express and purify the type I regulatory subunits, RI alpha and RI beta, the catalytic subunits C alpha and ...

To evaluate the significance of the renal resistive index (RI) as a noninvasive marker of renal histological damage and a prognostic indicator, we examined RI by Doppler ultrasonography in 202 chronic kidney disease (CKD) patients who underwent renal biopsy. RI increased as the CKD stage progressed and correlated with age, systolic blood pressure, estimated glomerular filtration rate (eGFR), an...

7KH JHQUH RI PDWKHPDWLFV ZULWLQJ KDV VHYHUDO GLVWLQFWLYH IHDWXUHV WKDW SRLQW WR VRPH RI WKH ZHDNQHVVHV RI FXUUHQW GLJLWDO GRFXPHQWV 6RPH RI WKHVH ZHDNQHVVHV DUH VXUSULVLQJ :KLOH LW PLJKW EH H[SHFWHG WKDW WKH LPSRUWDQFH RI IRUPDWWLQJ DQG VSHFLDO V\PEROV LQ PDWKHPDWLFV ZULWLQJ ZRXOG SRVH FKDOOHQJHV IRU GLJLWDO GRFXPHQWV WKH OLQNHG FKXQNHG VW\OH RI PDWKHPDWLFV ZULWLQJ ZLWK LWV 7KHRUHPV /HPPDV &RUR...

,Q WKLV SDSHU D QHZ GHVFULSWLRQ PHWKRG LV SUHVHQWHG ,W LV EDVHG RQ WKH FRPELQDWLRQ RI VWUXFWXUDO DQG VWDWLVWLFDO DSSURDFKHV DQG LV DSSOLHG WR WKH SUREOHP RI XQFRQVWUDLQHG LVRODWHG KDQGZULWWHQ FKDUDFWHU UHFRJQLWLRQ &KDUDFWHUV DUH SUHOLPLQDULO\ GHFRPSRVHG LQ WHUPV RI VWUXFWXUDO SULPLWLYHV FLUFXODU DUFV DQG VXFFHVVLYHO\ GHVFULEHG LQ WHUPV RI VWDWLVWLFDO IHDWXUHV JHRPHWULFDO PRPHQWV VXLWDEO\ QRUPDO...

7KH PRWLYDWLRQ IRU XVLQJ IRUPDO PHWKRGV LQ WKH FRQWH[W RI WUXVWHG GHYHORSPHQW VWHPV SULPDULO\ IURP WKHLU DELOLW\ WR HQVXUH SUHFLVLRQ FRQVLVWHQF\ DQG DGGHG DVVXUDQFH GXULQJ WKH HODERUD WLRQ RI VHFXULW\ UHTXLUHPHQWV DFURVV GLIIHUHQW VWDJHV LQ WKH GHYHO RSPHQW RI D WUXVWHG FRPSXWLQJ V\VWHP 7KH VXEMHFW PDWWHU RI IRUPDO PRGHOV DQG VSHFLILFDWLRQV FDQ EH LOOXVWUDWHG E\ WKH YDULRXV NLQGV RI VHFXULW\ DW...

Extracellular proteases of Porphyromonas gingivalis specific for arginyl peptide bonds are considered to be important virulence factors in periodontal disease. In order to determine the number, inter-relationship and kinetic properties of these proteases, extracellular enzymes with this peptide-bond specificity were purified and characterized from P. gingivalis W50. Three forms, which we denote...

AIMS Renal insufficiency (RI) is a strong predictor of adverse outcome in patients with heart failure (HF). We aimed to determine the prevalence of RI being unrecognized and its significance in patients hospitalized with HF. METHODS AND RESULTS We analysed data from a prospective survey of 4102 hospitalized patients with HF. RI [defined as estimated glomerular filtration rate (eGFR) <60 mL/mi...

The National Hurricane Center (NHC) and Statistical Hurricane Intensity Prediction Scheme (SHIPS) databases are employed to examine the large-scale characteristics of rapidly intensifying Atlantic basin tropical cyclones. In this study, rapid intensification (RI) is defined as approximately the 95th percentile of over-water 24-h intensity changes of Atlantic basin tropical cyclones that develop...