Rhubarb, a famous traditional Chinese medicine, shows wide range of physiological activities and pharmacological benefits. Rhubarb anthraquinones are perceived as the pharmacologically active compounds understanding metabolism them is crucial to assure safety effectiveness clinical application. In this study, pharmacokinetics, tissue distribution excretion five rhubarb (aloe-emodin, rhein, emod...

According to traditional Chinese medicine theory (1), pancreatitis is a " splenic precordial pain " or " hypochondriac pain, " caused by excessive drinking , gluttony, or gloomy mood, or secondary to biliary tract ascariasis, gallstones, and other diseases. To date, no specific drugs have been able to cure acute pancreatitis, and management is typically conservative. Traditional Chinese and Wes...

The present investigation is on bioethanol and biohydrogen production from oxalate-rich rhubarb leaves which are an underutilized residue of cultivation. Rhubarb can be the feedstock for using thermophilic, anaerobic bacteria. fermentation second-generation biomass to biofuels by Thermoanaerobacter has already been reported as well their high ethanol hydrogen yields although not examined this p...

Some plant compounds or herb mixtures are popular alternatives to conventional therapies and contain organic compounds that bind to some nuclear receptors, such as the estrogen receptor (ER), to exert various biological effects. We studied the effect of various herbal extracts on ERalpha and ERbeta isoforms. One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbe...

Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group receive...

Mercury (Hg) causes severe nephrotoxicity in subjects with excess exposure. This work attempted to identify whether a natural medicine--rhubarb--has protective effects against mercuric chloride (HgCl₂)-induced acute renal failure (ARF), and which of its components contributed most to the treatment. Total rhubarb extract (TR) were separated to the total anthraquinones (TA), the total tannins (TT...

Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antibiotics on the purgative action of DKT, rhubarb, or sennoside A, a constituent ...

Rhubarb is often used to establish chronic diarrhea and spleen (Pi)-deficiency syndrome animal models in China. In this study, we utilized the enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) method to detect changes in bacterial diversity in feces and the bowel mucosa associated with this model. Total microbial genomic DNA from the small bowel (duodenum, jej...

Introduction Herbal medicine has been recognized as one of useful treatments for chronic liver diseases. Inchinko-to (TJ135) consists of Artemisia Capillaris Spike, Gardenia Fruit and Rhubarb Rhizome. Artemisia Capillaris Spike and Gardenia Fruit promote bile secretion [1,2]. Rhubarb Rhizome is used for constipation. Rhubarb Rhizome contains anthraquinone derivatives, such as aloe emodin and em...