Objective: The present investigation is aimed to develop and validate, a simple, consistent sensitive stability-indicating reverse phase-high performance liquid chromatography (RP-HPLC) method for the determination of oral anti-diabetic drug Canagliflozin in bulk pharmaceutical dosage form as per International Council Harmonization Technical Requirements Pharmaceuticals Human Use (ICH-Q2 (R1))....

A simple, precise and specific reverse phase high performance liquid chromatographic method has been developed and validated for the determination of raltegravir in blood. The HPLC separation was carried out by reverse phase chromatography on Shimadzu HPLC system consisted of Welchrom 5μ C18 column (250 X 4.6 mm), SPD 10A UV detector and LC 10AD Pumps. Rheodyne injector with 20 μl loop with a m...

the occurrence and fate of trace-level contamination of pharmaceuticals in the aquatic environment has been recognized as one of the emerging issues in environmental chemistry. the effluents of wastewater treatment plants, usually directly emitted to the environment, often contain the anti-inflammatory drug diclofenac. diclofenac was chosen because it is of high consumption; by background liter...

in published high performance liquid chromatographic (hplc) methods for analysis of topiramate (tpm) in pharmaceutical dosage forms and raw materials refractive index detector (rid) has been used which is not available in many laboratories and has low sensitivity. we described a new, sensitive and simple hplc method for determination of topiramate in pharmaceutical forms and in-virto dissolutio...

in this study, caffeic acid (ca) and its three derivatives including 3-caffeoylquinic acid (3-cqa, neochlorogenic acid), 4-caffeoylquinic acid (4-cqa, cryptochlorogenic acid), and 5-caffeoylquinic acid (5-cqa, chlorogenic acid) were identified in bupleurum chinense aerial parts using reverse-phase high-performance liquid chromatography (rp-hplc) with photodiode array (pda) detector, reference c...