The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it i...

     The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it i...

with development of technology and science and continuous increase in productivity, product life cycles are shortened and customer demands are more personalized and diversified, which makes companies face with ever changing and unpredictable competitive environment. therefore, rapid response to market competition has become one of the main focuses and the competitive advantages. today, one of t...

Pulmonary arterial hypertension (PAH) is an incurable disease characterized by a progressive increase in pulmonary vascular resistance leading to right heart failure. Carbon monoxide (CO) has emerged as a potently protective, homeostatic molecule that prevents the development of vascular disorders when administered prophylactically. The data presented in this paper demonstrate that CO can also ...

the objective of the current study was to evaluate the reproducibility of a reverse transcriptase pcr (rt-pcr)-based technique to differentiate viable and dead salmonella cells in raw and sterilized milk. the microorganism was initially inoculated into the milk samples followed by incubating at 37°c for 4 h prior to inactivation by heat at 80°c for 10 min. the treated and non-treated samples we...

objective: the organotypic co-culture is a well-known technique to examine cellular interactions and their roles in stem cell proliferation and differentiation. this study aims to evaluate the effects of dermal fibroblasts (dfs) on epidermal differentiation of adipose-derived stem cells (ascs) using a three-dimensional (3d) organotypic coculture technique. materials and methods: in this experim...

In this work needle like hydroxy apatite were synthesized in a reverse microemulsion droplets of water in cyclohexane, separated by a cationic surfactant and co-surfactant, in the presence of Na-polyacrylate (PAA) as an anionic polyelectrolyte. Characterization of the as formed HAp nanoparticles at the room temperature were carried out by X-ray diffraction (XRD) and Fourier transform infrared s...

We report the likely detection of near-infrared 2.29 μm first overtone carbon monoxide (CO) emission from the young supernova (SN) remnant Cassiopeia A (Cas A). The continuum-subtracted CO filter map reveals CO knots within the ejecta-rich reverse shock. We compare the first overtone CO emission with that found in the well studied supernova SN 1987A and find ∼30 times less CO in Cas A. The pres...