Background & Aim: Hypertension is an incurable disease which has become a common major risk factor for many cardiovascular diseases worldwide. Besides increasing the risk of heart diseases and stroke, hypertension can also lead to other health conditions such as renal disease and diabetes. The prolong use of orthodox antihypertensive are usually associated with many side effect...

OBJECTIVE To estimate the risk of infection with HIV (HIV 1 or HIV 2, or both) from transfusion of a screened unit of blood in a high prevalence area in west Africa. DESIGN Retrospective cohort study for January-July 1991. SETTING National Blood Transfusion Centre, Abidjan, Côte d'Ivoire. SUBJECTS Repeat donors (5831 units of blood) and first time donors (5076 units) in the first five mon...

BACKGROUND In the few studies available, the risk of developing systemic reactions (SR) to hymenoptera stings in patients with previous large local reactions (LLRs) to stings ranges from 0 to 7 %. We evaluated both retrospectively and prospectively the risk of SRs in patients with LLRs to stings. METHODS An overall number of 477 patients, 396 with an SR as the first manifestation of allergy a...

In 2011, the monovalent rotavirus vaccine was introduced into a universal immunization program in Quebec (Canada). This retrospective cohort study assessed vaccine effectiveness (VE) in preventing acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) hospitalizations among children <3 y living in the Quebec Eastern Townships region according to socioeconomic status (SES). Data were g...

OBJECTIVE To determine whether the incidence of in situ cervical carcinoma was increased among a cohort of women who received transcervical insertions of quinacrine hydrochloride pellets into the uterine cavity as a method of nonsurgical sterilization. DESIGN Retrospective review of Papanicolaou (Pap) test results, comparing incidence of high-grade lesions among quinacrine acceptors with a co...

Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbations. It has yet to be determined whether leukotriene receptor antagonist (LTRA) treatment prevents URI-induced acute asthma exacerbations in adults. The objective of the present study was to evaluate the preventive effects of LTRA treatment on URI-induced acute asthma exacerbations. The inciden...

A retrospective study conducted at central Haiti's Albert Schweitzer Hospital in the June 1991-January 1992 period sought to assess the numbers of malaria cases seen at the hospital in 1982-1991, the distribution of cases by age and sex in 1988-1991, and the validity of official reports indicating an overall decline in malaria cases. Review of the hospital's laboratory records (1982-1986, 1988-...

BACKGROUND Sjögren's syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population. METHODS We conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS gro...

Histories of the usage of oral contraceptives and other estrogens were obtained from 320 women 20-49 years of age who had pathologically confirmed diagnoses of benign breast disease made at Washington County Hospital in Hagerstown, Maryland, during the period 1968 through 1972. Similar histories were obtained from 320 controls matched for race, sex, age, residence in county, and willingness to ...

The therapeutic landscape for advanced melanoma has recently been transformed by several novel agents (immune checkpoint inhibitors and molecular-targeted agents). The prospective, multi-site, observational study IMAGE (ipilimumab: management of advanced melanoma in real practice) included a retrospective cohort to describe real-world treatment prior to approval of the immune checkpoint inhibit...