We report on a 36-year-old woman treated with the anti PD-1 antibody Pembrolizumab for metastatic cutaneous melanoma in the first line setting. She achieved a complete response and then relapsed with metastases to the vitreous cavity with an associated angiographically determined retinal vasculitis. Vitreous metastasis without choroidal involvement is unusual and may be due to individual cell e...

•Metastatic disease should be considered in cervical cancer patients presenting with eye pain and vision complaints.•Distant metastasis involving less common organ sites, such as the eye, suggest a poor prognosis with short life expectancy.•In cases of cervical cancer metastatic to the eye, radiotherapy may decrease the incidence of retinal detachment and vision loss.

purpose: to evaluate the success rate of vitrectomy in giant retinal tears (gtr) and factors influencing it. methods: in an interventional case series, hospital records of 68 eyes of 63 patients operated for grt were reviewed. standard three port vitrectomy plus placement of an encircling band, retinopexy, and internal tamponade was performed for all eyes. possible influencing factors including...

Aldehyde dehydrogenase (ALDH) is a cancer stem cell marker. Retinoic acid has antitumor properties, including the induction of apoptosis and inhibition of proliferation. Retinal, the precursor of retinoic acid, can be oxidized to retinoic acid by dehydrogenases, including ALDH. We hypothesized that retinal could potentially be transformed to retinoic acid with higher efficiency by cancer stem c...

Eales' disease is an idiopathic obliterative retinal vasculopathy that is treated with laser photocoagulation, and/or vitrectomy. In order to determine visual outcomes and regression of retinal neovascularization following scattered peripheral retinal photocoagulation, and/or vitrectomy in cases with Eales' disease, we did a retrospective study of the records of these patients treated in La...

Introduction: According to the literature, Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE), and Artemio Venule Ratio (AVR) are three important markers in determining the changes of retinal artery. These markers are employed as an indicator of cardiovascular effects in workers. This study aimed to evaluate the changes in retinal micro vascular responses in...

Introduction Blue light is a part of the spectrum with the highest energy content, which can reach the retina. The damage that it can cause to the retina is called photochemical or blue-light retinal injury. For the retinal injury assessment of the photochemical and aphakic retinal hazards in the wavelength range of 300-700 nm, use of effective spectral radiance limits (W.m-2.sr-1) seems to be ...

purpose : to report a case of congenital macular macrovessels case report : an 8-year-old girl was referred for decreased vision in her right eye. her best corrected visual acuity (bcva) in the right eye was 20/200 and in the left eye 20/20. anterior segment examinations were normal in both eyes. posterior segment examination of the right eye showed abnormal macrovessels crossing the macula and...

Strategies to target angiogenesis include inhibition of the vessel-stabilizing properties of vascular pericytes. Pericyte depletion in early-stage non-hypoxic tumors suppressed nascent angiogenesis, tumor growth, and lung metastasis. In contrast, pericyte depletion in advanced-stage hypoxic tumors with pre-established vasculature resulted in enhanced intra-tumoral hypoxia, decreased tumor growt...

The uveals metastases are the most frequent malignant tumours of the eye, 10 times more than the melanoma. Their rate of which has occurred is estimated in the recent literature between 2 and 38%, their period of apparition are more often at the final stage of the neoplasma. Our work present the rare case of 40 year old patient, in quite condition general, addressed to our consultation for bila...