We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects w...

Assisted reproductive techniques (ART) have become part of the routine care, with a preva‐ lence ranging from 0.1 to 3.9% of all live born children in Europe and an average of 2% in some parts of the USA [1]. Despite the initial dramatic improvements in success rates and significant increments in ART uptake, the live birth rate resulting from these techniques has recently plateaued. Unfortunate...

Abstract Background Polymorphism A1298C of the methylenetetrahydrofolate-reductase (MTHFR) gene has been implicated in spontaneous abortion. In this study, we determined the allele and genotype frequencies of this polymorphism in recurrent spontaneous abortion (RSA) and implantation failure after in vitro fertilization (IVF). Materials and Methods We performed a case–control study on 60 wom...

Partial or complete fertilization failure after IVF was reported in 5-10% of cycles. Total fertilization failure in patients with normal sperm parameters is rare but very stressful incident after IVF. To rescue the IVF cycles after total fertilization failure, ICSI of unfertilized oocytes after initial insemination has been reported.We reviewed a 2 years experience of rescue ICSI and analyzed t...

Background: Endometrial receptivity is one of the most important factors in vitro fertilization (IVF) success rate. Many different methods have been suggested to enhance rate implantation IVF\ intracytoplasmic sperm injection (ICSI) cycles. injury, as an intentional trauma aimed at improving fertility results, has gained significant popularity among women seeking pregnancy. This study was condu...

BACKGROUND There are few effective approaches to infertile patients with repeated failure in IVF-embryo transfer therapy. Since recent evidence suggests that some populations of maternal immune cells positively support embryo implantation, we have developed a new approach using peripheral blood mononuclear cells (PBMCs). METHODS Patients who had not experienced successful pregnancy despite fo...

BACKGROUND Preimplantation genetic screening (PGS) has increasingly been used in the past decade. Here we present a systematic review and meta-analysis of RCTs on the effect of PGS on the probability of live birth after IVF. METHODS PubMed and trial registers were searched for RCTs on PGS. Trials were assessed following predetermined quality criteria. The primary outcome was live birth rate p...

BACKGROUND Recurrent spontaneous abortion (RSA) and in vitro fertilization (IVF) failure with unknown causes are the controversial issues that are probably related to the immune system. OBJECTIVE To compare circulating NK cells expressing activation and inhibition surface markers between patients with RSA and IVF failure with those of healthy multiparous and successful IVF control women, resp...

Objective: Repeated implantation failure (RIF) is a condition in which the embryos implantation decreases in the endometrium. So, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. Materials and methods: In this simple randomized clinical trial (RCT), a total of 120 patients were selected. The participants were less than 40 years old, and they are in thei...

BACKGROUND Failure of IVF treatment after a number of cycles can be devastating for couples. Although mild IVF strategies reduce the psychological burden of treatment, failure may cause feelings of regret that a more aggressive approach, including the transfer of two embryos, was not employed. In this study, the impact of treatment failure after two or more cycles on stress was studied, followi...