AIMS To characterize the effects of long-term β-adrenergic receptor stimulation on Rem protein and mRNA expression in rat heart and possible involvement of miR-132. METHODS Adult rats were treated with isoproterenol (ISO, 150 µg.kg.h(-1)) for 2 d and Rem, miR-132, and α1c (the principal subunit of Cav1.2 channels) were measured at protein and mRNA levels with western blot and quantitative rev...

Background & Aims: Sleep disorders are common complains in patients with cerebral stroke; studies on these issues are limited. We aimed to evaluate the sleep changes in patients with supratentorial ischemic stroke. Methods: In this cross sectional study, 38 patients (19 patients in supratentorial ischemic stroke group and 19 people in control group) were evaluated. Total sleep time, sleep effic...

Recent experimental studies investigating the neuronal regulation of rapid eye movement (REM) sleep have identified mutually inhibitory synaptic projections among REM sleep-promoting (REM-on) and REM sleep-inhibiting (REM-off) neuronal populations that act to maintain the REM sleep state and control its onset and offset. The control mechanism of mutually inhibitory synaptic interactions mirrors...

Rapid eye movement sleep in males is characterized by penile erection along with EEG desynchronization, muscle atonia, ponto-geniculo-occipital waves, and rapid eye movements (REM). The central neural mechanisms regulating sleep related erections (SREs) are not known. Recently, the lateral preoptic area has been shown to contribute in sleep-related erectile mechanisms. The present study was con...

* To whom all correspondence should be addressed Telephone: (443) 885-4687 Fax: (443) 885-8285 E-mail: [email protected] Running head: REM-sleep deprivation, metabolic rate, and UCP-1 gene expression

Acetylcholinesterase (AchE) is a large glycoprotein that, aside from its known cholinolytic activity, co-exists with other transmitter systems and possesses other functions. In the present study, the effects of short-term rapid-eye-movement sleep deprivation (REM-SD) on AchE activity in the anterior hypothalamic area have been investigated. Using the flower-pot method, adult male albino ra...

hund narcoleptics. Similar analysis of cDNA from narco-leptic Labradors showed a 123 bp deletion of exon 6 and a G to A transition in the 5Ј splice junction consensus sequence. Thus, the genetic abnormality in Doberman Human narcolepsy, a chronic disorder that occurs in narcoleptics differs from that in Labrador narcoleptics, about 1 in 3000 individuals, is characterized by (1) exces-but both i...

Transdermal scopolamine has been widely used for the prevention of motion-sickness by travelers due to its potent anticholinergic effects and the ease of administration. Nevertheless, its effects on sleep physiology are not known, despite the wellknown fact that the administration of scopolamine as an injection or an oral form could influence the sleep architecture, especially prolonging rapid ...