Then, drug release kinetics follows a well defined behavior in order to supply the maintenance dose enabling the attainment of the desired drug concentration.

background chitosan is a naturally occurring biopolymer which has been widely used in a variety of biomedical applications including local antibiotic delivery due to its excellent mechanical properties, biodegradability and biocompatibility. beads are spherical, porous carriers which are prepared from various materials including chitosan. objectives the current study aimed to fabricate a new co...

this study examines the controlled release behavior of both water-soluble (acetaminophen, caffeine, theophylline and salicylic acid) and water insoluble (indomethacin) drugs derived from caesalpinia pulcherrima seed gum isolated from caesalpinia pulcherrima kernel powder. it further investigates the effect of incorporating diluents such as microcrystalline cellulose and lactose on caffeine rele...

nonexchangeable soil-k release rate can significantly affect k dynamics and it's bioavailability during plant growth. in this study, twelve soil samples taken from different wheat cropping regions of iran were incubated with nabph4 to (i) investigate the kinetics of nonexchangeable k release and (ii) to compare the ability of various kinetic equations (zero-, first- and second-order, parab...

Skin drug delivery systems with controlled release are suitable means for the local transfer of pharmaceutical compounds to the damaged and healthy layers of skin. Nanofibrous membrane prepares uniform moisture in the wound environment with less accumulation of fluid secretion due to its variable pore size. Electrospinning takes advantage of using herbal extracts in the form of electrospun nano...

Skin drug delivery systems with controlled release are suitable means for the local transfer of pharmaceutical compounds to the damaged and healthy layers of skin. Nanofibrous membrane prepares uniform moisture in the wound environment with less accumulation of fluid secretion due to its variable pore size. Electrospinning takes advantage of using herbal extracts in the form of electrospun nano...

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

the purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. polyethylene oxide (peo) and hydroxypropyl methylcellulose (hpmc) were evaluated for matrix-forming properties. a simplex lattice design was applied to systemically optimize the drug release profile. the amounts of peo wsr 303, hpmc k15m and sodium bicarbonate were selected as independen...