controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (hpmc) as the matrix former. the effects of the viscosity grades of hpmc and hpmc/lactose ratio and ethylcellulose (ec)/sodium carboxymethylcellulose (nacmc) and their concentrations on the release behavior of phenobarbital from hpmc matrices were invest...

nonexchangeable soil-k release rate can significantly affect k dynamics and it's bioavailability during plant growth. in this study, twelve soil samples taken from different wheat cropping regions of iran were incubated with nabph4 to (i) investigate the kinetics of nonexchangeable k release and (ii) to compare the ability of various kinetic equations (zero-, first- and second-order, parab...

background the goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability. material and methods to select the best formulation, formulations with different concentration of carbomer and hpmc were evaluated for their appearance. then evaluated for physicochemical characteristics such as rheologic behavior...

the purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose k 100 (hpmck) and eudragit l 100. the granules were prepared by wet granulation method and thereby formulated as f-1, f-2. f-3 and...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

in this study, an in-house multi-dimensional code has been developed which simulates the combustion of n-heptane in a homogeneous charge compression ignition (hcci) engine. it couples the flow field computations with detailed chemical kinetic scheme which involves the multi-reactions equations. a chemical kinetic scheme solver has been developed and coupled for solving the chemical reactions an...

      The purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. Two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose K 100 (HPMCK) and Eudragit L 100. The granules were prepared by wet granulation method and thereby formulated as F-1, F-2. F...

frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. in the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...