Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties maximum therapeutic efficacy. The regulates the rate at which is released. Because it facilitates prolonged release, major excipient in formulation retardant. technology may promote patient compliance efficiently treat chronic illnesses by d...

Adhesion layers, required to stabilize metallic nanostructures, dramatically deteriorate the performances of plasmonic sensors, by severely damping the plasmon modes. In this article, we show that these detrimental effects critically depend on the overlap of the electromagnetic near-field of the resonant plasmon mode with the adhesion layer and can be minimized by careful engineering of the lat...

With advances in the plasmonics and metamaterials research field, it has become more and more important to fabricate thin and smooth Au metal films in a reliable way. Here, by thin films we mean that their average height is below 10 nm and their average roughness is below 5% of the total thickness. In this article, we investigated the use of amino- and mercaptosilanes to increase the adhesion o...

In this article we introduce and implement a branch-and-cut-and-price algorithm for the Multiple Depot Vehicle Routing Problem with Stochastic Demands. We consider the delivery of a common commodity to a set of customers from a set of non-capacitated depots. The demand of each customer is described by a random variable, whose actual value becomes known upon arrival at the customer. The deliveri...

Considerable evidence suggests that variations in the properties of topological insulators (TIs) at the nanoscale and at interfaces can strongly affect the physics of topological materials. Therefore, a detailed understanding of surface states and interface coupling is crucial to the search for and applications of new topological phases of matter. Currently, no methods can provide depth profili...

Introduction:The post-surgical management of patients with differentiated thyroid cancer include ablation of remnant local and distant metastatic tissues with 131I therapy, which accentuates isolation of the patient in order to avoid unnecessary radiation exposure to the care givers, general public and the environment. The duration of isolation is subject to the redu...

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...