ASXL1 is frequently mutated in a spectrum of myeloid malignancies with poor prognosis. Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice; however, the underlying molecular mechanisms remain unclear. We report that ASXL1 interacts with the cohesin complex, which has been shown to guide sister chromatid segregation and regulate gene expression. Loss of Asxl1 impairs the cohesin...

‎The problem of shrinkage testimation (test-estimation) for the Rayleigh scale‎ ‎parameter θ based on censored samples under the reflected‎ ‎gamma loss function is considered‎. We obtain the minimum risk‎ ‎estimator among a subclass and compute its risk‎. ‎A shrinkage‎ ‎testimator based on acceptance or rejection of a null hypothesis&lr...

1 Also associated with LE2I lab, The University of Burgundy, IUT Le Creusot, 71200 Le Creusot, France Abstract: Sensor placement for 3-D modeling is a growing area of computer vision and robotics. The objective of a sensor placement system is to make taskdirected decisions for optimal pose selection. We propose a Next Best View (NBV) solution to the sensor placement problem. Our algorithm compu...

perrault's syndrome (p.s.) is rare. the combination of gonadal dysgenesis and hearing loss was accompanied by 46,xxkaryotype in three sisters with parental consanguineous marriage. genetic investigation revealed normal female karyotype, positive liarr and negative fluorescence ipj-bodies, which was confirmed by molecular study on the basis of fluorescence in situ hybridization (pish), with appl...

In this position paper, we submit a synthesis of theoretical models based on physiology, non-equilibrium thermodynamics, and non-linear time-series analysis. Based on an understanding of the human organism as a system of interconnected complex adaptive systems, we seek to examine the relationship between health, complexity, variability, and entropy production, as it might be useful to help unde...

Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for hair cell mechanotransduction. We questioned whether hair cells and the stria interdepend for survival by using two mouse models. Atoh1 condit...