bioequivalence study is a scientific and practical method used to compare the quality of a generic drug with a reference product. this study aimed to examine the bioequivalence of two closantel formulations produced with different sources of raw material by a domestic pharmaceutical company. due to long half- life of closantel, the study carried out by a parallel method. thirty sheep were divid...

in this paper, we give some characterizations for legendre spherical, legendre normal and legendre rectifying curves in the 3-dimensional sasakian space. furthermore, we show that legendre spherical curves are also legendre normal curves. in particular, we prove that the inverse of curvature of a legendre rectifying curve is a non-constant linear function of the arclength parameter.

Hilbert’s two-dimensional space-filling curve is appreciated for its good locality properties for many applications. However, it is not clear what is the best way to generalize this curve to filling higher-dimensional spaces. We argue that the properties that make Hilbert’s curve unique in two dimensions, are shared by 10 694 807 structurally different space-filling curves in three dimensions. ...

BACKGROUND: Due to several factors, such as gastrointestinal's diseases and difficulty in feeding, children with Spastic Quadriplegic Cerebral Palsy tend to present nutritional deficits. OBJECTIVE: To assess the nutritional status of pediatric patients with Spastic Quadriplegic Cerebral Palsy according to reference curves for this population and with the measures of folds and circumferences...

BACKGROUND many instruments are available to identify frail older adults who may benefit from geriatric interventions. Most of those instruments are time-consuming and difficult to use in primary care. OBJECTIVE to select a valid instrument to identify frail older adults in primary care, five simple instruments were compared. METHODS instruments included clinical judgement of the general pr...