The mechanism by which prostaglandin E2 (PGE2) inhibits sodium absorption (JNa) in the rabbit cortical collecting duct (CCD) was explored. PGE2 activates at least three signaling mechanisms in the CCD: (a) by itself PGE2 increases cAMP generation (b) PGE2 also inhibits vasopressin-stimulated cAMP accumulation, and (c) PGE2 raises intracellular calcium([Ca++]i). We tested the contribution of the...

A composite quadric model (CQM) is an object modeled by piecewise linear or quadric patches. We study the continuous detection problem of a special type of CQM objects which are commonly used in CAD/CAM, that is, the boundary surfaces of such a CQM intersect only in straight line segments or conic curve segments. We present a framework for continuous collision detection (CCD) of this special ty...

BACKGROUND A chronic compressed dorsal root ganglion (CCD) in rat produces pain behavior and an enhanced excitability of neurons within the compressed ganglion. Kir2.1 is an inwardly rectifying potassium channel that acts to stabilize the resting potential of certain cell types. We hypothesized that an inducible expression of Kir2.1 channels in CCD neurons might suppress neuronal excitability i...

Cleidocranial dysplasia (CCD), a skeletal disorder characterized by delayed permanent tooth eruption and other dental abnormalities, is caused by heterozygous RUNX2 mutations. As an osteoblast-specific transcription factor, RUNX2 plays a role in bone remodeling, tooth formation and tooth eruption. To investigate the crosstalk between RUNX2 and 1α,25-dihydroxyvitamin D3 (1α,25-(OH)2D3) in human ...

Significant motion artifacts may arise in conventional spectral-domain optical coherence tomography due to sample or probe motion during the exposure time of a CCD array. We show, for the first time to our knowledge, that the motion artifacts can be greatly reduced by short illumination of individual CCD pixels and that this can be accomplished by use of two distinct classes of light sources: b...

The Atlantic is the only ocean basin almost entirely surrounded by passive margins, and a major global long-term sink of carbonate carbon that has evaded subduction. Quantifying history accumulation in been limited absence well-defined regional compensation depth (CCD) models. We determine CCD for northern North Atlantic, central South use these reconstructions to compute mass flux tectonic fra...

One of the main drivers for determining the operating temperature of the Solar-B EIS CCDs is the possibility that substantial Charge Transfer Inefficiency may occur towards the end of the mission lifetime. The magnitude of the CTI has been discussed in several technical notes (references 1-3) and this information has been used to judge the optimum and minimum operating temperature of the CCD (r...

The SLD upgrade CCD vertex detector (VXD3) is described. Its 307 million pixels are assembled from 96 3.2 Mpixel CCDS of 13 cm2 each. The system has evolved from the pioneering CCD vertex detector VXD2, which has operated in SLD since 1992. The CCDS of VXD3 are mounted on beryllium ladders in three cylinders, providing three space point measurements along each track of about 5 microns resolutio...