AIM To compare the performance of keratoconus, penetrating keratoplasty (PK), and control subjects on clinical tests of contrast and glare vision, to determine whether differences in vision were independent of visual acuity (VA), and thereby establish which vision tests are the most useful for outcome studies of PK for keratoconus. METHODS All PK subjects had keratoconus before grafting and n...

Keratoconus is the most common ectatic disorder of the corneal. Genetic and environmental factors may contribute to its pathogenesis. The focus of this article is to summarize current research into the complex genetics of keratoconus. We discuss the evidence of genetic etiology including family-based linkage studies, twin studies, genetic mutations, and genome-wide association studies. The gene...

Objective: To compare Corvis ST (Oculus Wetzlar, Germany) and Pentacam (Oculus) derived indices to detect normal cornea, keratoconus for mefruste keratoconus.
 Study Design: Comparative cross sectional study.
 Place Duration of Study: Armed Forces Institute Ophthalmology (AFIO), Rawalpindi, from Feb Jul 2019.
 Methodology: Following strict inclusion criteria 90 patients were enro...

PURPOSE To formulate and test an algorithm using minimal topographic criteria for accurately diagnosing clinical keratoconus. SETTING Subspecialty cornea practice and Keratoconus Genetic Research Project. METHODS Both eyes of 86 keratoconic patients who had never worn contact lenses and 195 normal participants were studied with the TMS-1 videokeratoscope to evaluate the KISA% index, an algo...

PURPOSE Keratoconus is a bilateral noninflammatory progressive corneal disorder with complex genetic inheritance and a common cause for cornea transplantation in young adults. A genomewide linkage scan in keratoconus families identified a locus at 5q23.2, overlapping the gene coding for the lysyl oxidase (LOX). LOX encodes an enzyme responsible for collagen cross-linking in a variety of tissues...

PURPOSE The purpose of this work was to identify potential tear-film based proteins expressed in keratoconus. METHODS Recruited subjects were normal gas permeable (GP) contact lens wearers, keratoconus subjects wearing GP contact lenses, and keratoconus subjects without contact lenses. Subjects wearing soft lenses or having previous ocular surgeries were excluded from participating. Approxima...

AIM To study the survival and visual outcome of penetrating keratoplasty in an African setting. METHODS A retrospective analysis of 216 corneal grafts, performed on 203 eyes of 186 patients, at Kikuyu Hospital, Kenya over a 5 year period. RESULTS Half of the transplants were carried out for keratoconus with only 5% of the grafts being undertaken for corneal scarring caused by trachoma or me...

w ED1 + lmacmphages, monocytes and dendritic cellsl and ED2+ cells ImacrophaQoa ordvl agpear to have a role in comeal rejection followinp pen&ti~ kerato&~~ in the rat. In the fdlowinp presentation the distribution of ED1 and ED2 wsitive cdls in normal weal tissues of Lewis rats, the influence of comeal transpiantation and the efIeci of Cwlnspuin A lCsAl upon both types of wllr was examined. m 6...

PURPOSE To validate the estimation of corneal aberrations from videokeratography against a laser ray tracing technique that measured total eye aberrations, in eyes without keratoconus (ie, cornea-dominated wave aberrations). METHODS We measured total and corneal wave aberrations of three eyes diagnosed with keratoconus by slit-lamp microscopy and corneal topography: two eyes from one patient ...