Intimate two-way interactions between the implantation-competent blastocyst and receptive uterus are prerequisite for successful embryo implantation. In humans, recurrent/repeated implantation failure (RIF) may occur due to altered uterine receptivity with aberrant gene expression in the endometrium as well as genetic defects in embryos. Several studies have been performed to understand dynamic...

BACKGROUND Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppel-like factor 12 (KLF12) and Nur77 are novel regulators of decidualization. We investigated whether KLF12 impaired the decidualization of hESCs in recurrent...

BACKGROUND Repeated Implantation Failure (RIF) is one of the most intricate obstacles in assisted reproduction. The cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. OBJECTIVE To compare the cytokine profile in the endometrium of normal fertile women and those with repeated implantation failure. METHODS After enzymatic digestion o...

Aim This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan. Methods Fifty patients with a history of RIF with frozen-thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling...

hla-g is a tolerogenic molecule that expresses in cytotrophoblast cells and plays an important role in immune response suppression in maternal decidua. interactions between the extracellular domains of the hla-g protein with cell receptors of the immune system are well-known.this  study  investigated  the  association  between  hla-g  gene  polymorphism  with repeated implantation failure (rif)...

background: repeated implantation failure (rif) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one. objective: this study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in rif patients. materials and methods: twenty women with ...

Aspects of the immunological relationship between mother and conceptus still remain a mystery, although the recent advances in molecular biology have enlightened some of the parameters that participate in feto-maternal cross-talk during implantation. The atypical expression of major histocompatibility complex (MHC), the specific roles of some hormones and cytokines, as well as the temporal and ...

background: recurrent implantation failure is one of the most issues in ivf cycles.some researchers found that beneficial effects of endometrial scratching in womenwith recurrent implantation failure, while some authors demonstrated contrary resultsobjective: the present study aimed to investigate the effect of intrauterine. salineinfusion as a form of endometrial injury, during fresh in vitro ...

Background: The process of implantation involves the interaction of the human embryo and the uterine epithelium. Failure of implantation is a major reason for infertility in women and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Management of repeated implantation failure despite transfer of good-quality embryos still rema...

Objective: to compare diagnostic values of two dimensional trans-vaginal sonography (TVS) and office hysteroscopy (OH) for evaluation of endometrial pathologies in cases with repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). Methods and Materials: This prospective study was performed in Royan institute from December 2013 to January 2015. TVS was performed before hysteroscop...