BACKGROUND AND PURPOSE Dose escalation improves local control in prostate cancer. In this study we assess the feasibility of dose escalation to prostate and / or seminal vesicles to 76 Gy with intensity-modulated radiotherapy (IMRT); report data on dosimetry and acute toxicity in 40 patients at P. D. Hinduja National Hospital and Medical Research Center, Mumbai. MATERIALS AND METHODS In the p...

Background. To assess the feasibility of salvage intensity-modulated radiation Therapy (IMRT) and to examine clinical outcome. Patients and Methods. 57 patients were treated with salvage IMRT to the prostate bed in our center from January, 2007, to February, 2010. The mean prescription dose was 68 Gy in 34 fractions. Forty-four patients received concomitant androgen deprivation. Results. Doses ...

The aim of the study was to report the clinical results in patients with high-risk prostate cancer treated with pelvic intensity-modulated radiation therapy (IMRT) and simultaneous integrated boost (SIB) to the prostate area. A total of 110 patients entered our study, 37 patients presented with localized prostate cancer and radiological evidence of node metastases or ≥15% estimated risk of lymp...

BACKGROUND The small bowel (SB) represents the most important dose-limiting structure in pelvic radiotherapy (RT). However, we observed that the majority of rectal cancer patients who received preoperative pelvic intensity modulated RT (IMRT) developed acute tenesmus without watery diarrhea. The objective of this study is to determine if the RT dose to SB affects the acute lower gastrointestina...

Background: In unresectable metastatic rectal cancers, surgery of primary tumor remains highly debated. Pelvic Chemoradiotherapy (CRT) could allow sufficient local control in order to avoid major and sometimes mutilating surgery. Dose escalated CRT increase control. The aim this study was evaluate the feasibility tolerance a with radiation dose escalation using intensity modulated radiotherapy ...

Randomised trials have shown that preoperative radiotherapy in rectal cancer reduces the risk of locoregional recurrence when delivered either form a 1 week short course or long treatment combined with concurrent chemotherapy [1–6]. However, may also be associated long-term, treatment-related toxicity [7–10]. Compared three-dimensional conformal (3D-CRT), intensity-modulated (IMRT) has potentia...

BACKGROUND Our purpose was to report acute gastrointestinal (GI) and genitourinary (GU) toxicity rates for prostate cancer patients undergoing image-guided intensity modulated radiation therapy (IG-IMRT) with a daily endorectal water-filled balloon (ERBH2O), and assess associations with planning parameters and pretreatment clinical characteristics. METHODS The first 100 patients undergoing pr...

Purpose: To disclose effectiveness of substitution of conformal radiotherapy (CRT) with intensity-modulated radiotherapy (IMRT) in combined with 125I permanent seed brachytherapy(BT) in reducing a rectal dose-volume parameter recently proven to be correlated with late rectal bleeding after the combined radiotherapy. Materials/Methods: A CT image set obtained a month after BT was used for CRT an...

Background: The aim was to evaluate the benefit of technical advances for treatment planning: introduction of a hydrogel spacer, VMAT (volumetric modulated arc therapy) and a single biological organ at risk objective for the rectum and bladder. Initial standard was a step-and-shoot IMRT (intensity modulated radiotherapy) without a spacer and conventional organ at risk objectives.  Material...

Objectives: To determine the pathological response rates and toxicity and in patients with locally advanced rectal cancer treated with concurrent capecitabine and dose escalated intensity modulated radiotherapy (IMRT) Methods: Patients with stage II or III adenocarcinoma of the rectum were treated with preoperative concurrent capecitabine and IMRT. Dose of capecitabine was 825mg/m2, 5 days a we...