BACKGROUND.: About one third of patients with TIMI 3 after reperfusion have evidence of microvascular obstruction (MO) which represents an independent predictor of myocardial wall rupture. This explains all efforts made to prevent MO. Magnetic resonance imaging (MRI) has proved to be particularly useful in detecting MO. The aim of this study was to evaluate with MRI if different fibrinolytic re...

We describe a case of sudden and severe pulseless electrical activity in a 30 year old woman which was managed successfully with reteplase and heparin one day following an anterior cruciate ligament repair. The presentation of a sudden collapse with ECG findings of S1Q3T3, early precordial lead ST depression and partial right bundle branch block were indicative of an acute pulmonary embolus. Th...

OBJECTIVE To examine the frequency and determinants of re-infarction after thrombolytic treatment of ST-elevation myocardial infarction (STEMI). DESIGN Observational study of national registry. SETTING Emergency ambulance services and admitting hospitals in England and Wales. PATIENTS 35 356 patients with STEMI given thrombolytic treatment in 2005-6. MAIN OUTCOME MEASURES Re-infarction ...

Administration of intravenous reteplase might be a choice of treatment of acute ischemic stroke.

Thrombosis is one of the major causes of death worldwide. It occurs due to imbalance between prothrombotic and fibrinolytic pathway. The clot formation activates the endogenous fibrinolytic system, for conversion of plasminogen to plasmin. Plasmin degrades the fibrin clot, restoring blood flow to vital organs. Thus, fibrinolysis is a physiological mechanism designed to remove intravascular thro...

Coronary heart disease is the single largest cause of mortality in the UK with acute myocardial infarction (AMI) being responsible for the greatest amount of deaths. Improving perfusion to the myocardium to prevent further damage or death of the cardiac tissue is the aim of treating AMI. In the UK reperfusion is achieved either through the use of an thrombolytic agent (streptokinase, alteplase,...

BACKGROUND AND PURPOSE Early reocclusion of recanalized arteries has been observed after thrombolysis for acute coronary occlusion and has been attributed to platelet activation after exposure to thrombolytic agents. We conducted a retrospective study to determine the rate of reocclusion during intra-arterial thrombolysis for acute ischemic stroke and the effect of reocclusion on functional out...

We performed molecular dynamics simulations of Reteplase in the presence different excipients to study stabilizing mechanisms and identify role during freeze drying. To simulate freeze-drying process, we divided process into five distinct steps: (i) protein–excipient formulations at room temperature, (ii) ice-growth (iii)–(iv) partially solvated fully dried formulations, (v) reconstitution. Fur...