نتایج جستجو برای: receptors wnt

تعداد نتایج: 245839  

Journal: :The Biochemical journal 1998
T C Dale

The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell communication in diverse developmental processes. The loss or inappropriate activation of Wnt expression has been shown to alter cell fate, morphogenesis and mitogenesis. Recent progress has identified Wnt receptors and components of an intracellular signalling pathway that mediate Wnt-dependent transcription. T...

Journal: :Science 2007
Josipa Bilic Ya-Lin Huang Gary Davidson Timo Zimmermann Cristina-Maria Cruciat Mariann Bienz Christof Niehrs

Multiple signaling pathways, including Wnt signaling, participate in animal development, stem cell biology, and human cancer. Although many components of the Wnt pathway have been identified, unresolved questions remain as to the mechanism by which Wnt binding to its receptors Frizzled and Low-density lipoprotein receptor-related protein 6 (LRP6) triggers downstream signaling events. With live ...

Journal: :Cold Spring Harbor perspectives in biology 2012
Patricia C Salinas

Regulation of cell signaling by Wnt proteins is critical for the formation of neuronal circuits. Wnts modulate axon pathfinding, dendritic development, and synaptic assembly. Through different receptors, Wnts activate diverse signaling pathways that lead to local changes on the cytoskeleton or global cellular changes involving nuclear function. Recently, a link between neuronal activity, essent...

Journal: :The Journal of biological chemistry 2012
Shruti Goel Emily N Chin Saja A Fakhraldeen Scott M Berry David J Beebe Caroline M Alexander

A canonical Wnt signal maintains adult mammary ductal stem cell activity, and this signal requires the Wnt signaling reception, LRP5. However, previous data from our laboratory have shown that LRP5 and LRP6 are co-expressed in mammary basal cells and that LRP6 is active, leading us to question why LRP6 is insufficient to mediate canonical signaling in the absence of LRP5. Here, we show that at ...

Journal: :Journal of cell science 2008
Paola Bovolenta Pilar Esteve Jose Maria Ruiz Elsa Cisneros Javier Lopez-Rios

The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding domain on the Fz receptors, SFRPs were immediately characterised as antagonists that bind to Wnt...

Journal: :International Journal of Cancer 2021

The canonical Wnt signaling pathway is activated in numerous contexts, including normal and cancerous tissues. Here, we describe a synthetic cell-based therapeutic strategy that inhibits aberrant activity specific focuses without interfering with the tissues vivo. As proof of principle, generated triple transgenic zebrafish liver cancer model conditionally expressed human MET induced ectopic he...

Journal: :Cold Spring Harbor perspectives in biology 2014
Jennifer Green Roel Nusse Renée van Amerongen

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan receptors because their ligands were unknown. They are now known to contain functional extracellular Wnt-binding domains and are implicated in Wnt-signal transduction in multiple species. Although their signaling mechanisms still remain to be resolved in detail, both Ryk and Ror control important developme...

Journal: :Molecular pathology : MP 2002
R F Holcombe J L Marsh M L Waterman F Lin T Milovanovic T Truong

AIMS Signalling through the Wnt pathway is integrally associated with colon carcinogenesis. Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process. In other systems, increased Wnt signalli...

2017
Wei Zhang Wenyan Lu Subramaniam Ananthan Mark J. Suto Yonghe Li

Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors can respond to Wnt proteins to activate the canonical β-catenin pathway which is important for both initiation and progression of cancers. Disruption of the Wnt/β-catenin signal thus represents an opportunity for rational cancer preventi...

Journal: :The Journal of biological chemistry 2002
Chi-hwa Wu Roel Nusse

Secreted Wnt proteins have numerous signaling functions during development, mediated by Frizzled molecules that act as Wnt receptors on the cell surface. In the genome of Drosophila, seven Wnt genes (including wingless; wg), and five frizzled genes have been identified. Relatively little is known about signaling and binding specificities of different Wnt and Frizzled proteins. We have developed...

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