In the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (WSS) on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. The opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). The first group exposed to WSS in the pr...

Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...

In the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (WSS) on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. The opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). The first group exposed to WSS in the pr...

objective(s): atherosclerosis is an important risk factor for coronary heart disease. neuropeptide y (npy) and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to obesity and fat storage. the role of npy in atherosclerosis has not yet been fully studied, so this study was conducted to further investigate the effect of biie 0246, an npy receptor antagoni...

in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...

this study was conducted to investigate the possible involvement of the histaminergic system in themediation of ghrelin-induced feeding behavior in broiler chickens. in the trial 1, the effect ofintracerebroventricular (icv) injection of ghrelin on feed intake was examined in 3-h feed-deprived broilerchickens. in the trials 2 and 3, the chickens were received icv chlorpheniramine (an h1 recepto...

Abstract Objectives Peyronie’s disease (PD) is characterised by formation of a fibrotic plaque in the tunica albuginea which caused excessive myofibroblast presence and activity. A previous phenotypic screening campaign that tested 1,954 FDA-approved drugs for their ability to inhibit transformation PD-derived fibroblasts revealed 26 hits. Of these, we investigated following hits further; terfe...

background: considering that cannabinoids protect neurons against neurodegeneration, in this study, the neuroprotective effect of win55,212-2 in paraoxon induced neurotoxicity in pc12 cells and the role of the n-methyl-d-aspartate (nmda) receptor were evaluated. materials and methods: in this study pc12 cells were maintained in dulbecco's modified eagle’s medium (dmem+f12) culture medium supple...

This study was conducted to investigate the possible involvement of the histaminergic system in themediation of ghrelin-induced feeding behavior in broiler chickens. In the trial 1, the effect ofintracerebroventricular (ICV) injection of ghrelin on feed intake was examined in 3-h feed-deprived broilerchickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine (an H1 recepto...