objective(s): maternal high-fat diet has been shown to have deleterious effects on the offspring bones. however, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (evoo). the objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in a...

objective(s): maternal high-fat diet has been shown to have deleterious effects on the offspring bones. however, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (evoo). the objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in a...

This review focuses on the roles of oxylipids and receptor activator of nuclear factor-κB ligand signaling in calcific cardiovascular disease. Both intimal and valvular calcifications are closely associated with atherosclerosis, leading investigators to study the role of atherogenic oxidatively modified lipids (oxylipids). Results have identified the molecular signaling through which oxylipids ...

Purpose: To determine the regulation of the expression of osteoprotegerin and receptor activator of nuclear factor-kappa B ligand in human dental follicle cells by colony-stimulating factor-1, parathyroid hormone-related protein and bone morphogenetic protein-2. Materials and Methods: Primary human dental follicle cells were cultured. The fifth passaged human dental follicle cells were separate...

background: receptor activator of nuclear factor kappa b ligand (rankl) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.several reports indicated the presence of srankl in gingival crevicular fluid of patients with periodontal diseases. objective: to determine the presence of rankl in peri-implant crevicular fluid samples of implants with peri-implan...

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. I...

Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphog...