Surface coatings of the albumin-heparin conjugates were developed to improve the blood compatibility of polymeric materials. Glass, PVC, Biomer and cellulose acetate were coated with albumin-heparin conjugate and its adsorption and desorption behavior on glass in particular was studied using 3H and 51Cr radiolabeled conjugates. Precoated materials showed a significant prolongation of the Lee-Wh...

The adsorption of coagulation factors was studied in the presence of the following decalcifying agents: Ion exchange resins, ammonium citrate, ammonium oxalate, a mixture of potassium and ammonium oxalate, and sodium E.D.T.A. Whichever decalcifying technique was used, the results were similar and only the results using human citrated plasma (1 part of citrate 0.38% to 9 parts of blood) are repo...

We have studied the effects of two human pancreatic cancer and two human small cell lung cancer cell lines on clotting and platelet aggrega tion. Both pancreatic lines markedly shortened recalcification times and induced platelet aggregation. The lung cancer lines produced little short ening of recalcification times and no platelet aggregation. The clotting and aggregation activities of the pan...

Coagulation A bnormalities in Subarachnoid Hemorrhage • Coagulation and fibrinolytic studies were performed in 30 subarachnoid hemorrhage patients and 30 age-matched and sex-matched controls. Systemic abnormalities were detected in the following tests: recalcification time, fibrinogen, partial thromboplastin time, K value of thromboelastogram and euglobulin lysis time. The data suggest that sub...

The venom of the rhinoceros horned viper (Bitis nasicornis) has been studied in vitro and has been shown to be anticoagulant. This action appeared to be due to an effect on both the extrinsic and intrinsic blood thromboplastin mechanisms. The venom was also proteolytic and in purified caseinolytic systems activated plasminogen, enhanced the activation of plasminogen by streptokinase, and potent...

ARECENTLY published tabulation' of simple organic compounds reported to induce some weak fibrinolytic activity includes only compounds known to influence vasomotion (procaine, epinephrine, diethylaminoethanol). Studies in our laboratory concerning the influence of vasomotor drugs on the clotting mechanism have resulted in the observation that intravenously administered nicotinic acid induces ra...

To verify whether cancer procoagulant (CP), a cysteine proteinase procoagulant distinct from tissue factor (TF), is associated with leukemic cells, we assayed the procoagulant activity of blast cell extracts from 26 patients with different cytological subtypes of acute nonlymphoid leukemia (ANLL) according to the French-American-British classification. All the samples except two shortened the r...