Oncogenic ras provokes a senescent-like arrest in human diploid fibroblasts involving the Rb and p53 tumor suppressor pathways. To further characterize this response, we compared gene expression patterns between ras-arrested and quiescent IMR90 fibroblasts. One of the genes up-regulated during ras-induced arrest was promyelocytic leukemia (PML) protein, a potential tumor suppressor that encodes...

The EphA4 receptor tyrosine kinase is involved in numerous cell-signalling activities during embryonic development. EphA4 has the ability to bind to both types of ephrin ligands, the ephrinAs and ephrinBs. The C57BL/6J-Epha4rb-2J/GrsrJ strain, denoted Epha4(rb-2J/rb-2J), is a spontaneous mouse mutant that arose at The Jackson Laboratory. These mutants exhibited a synchronous hind limb locomotio...

Despite the existence of formal models to explain how chromosomal rearrangements can be fixed in a population in the presence of gene flow, few empirical data are available regarding the mechanisms by which genome shuffling contributes to speciation, especially in mammals. In order to shed light on this intriguing evolutionary process, here we present a detailed empirical study that shows how R...

Tlc variation of nagn.rization wirh ficld in high-icmFr.turc suFrconductors pas calculat.d by cxtcnding thc spin-8tair modcl of Ebn€r and Srroud lC. Ebocr and D. Stroud, phvs. Rcv. B il. 165 (1965)l to incorporalc domains insid! thc Srains. Trro couplin8 .n.r8i.3 wcrc urcd, one bcrwen domains in rhc sinc grain, and a ficld{.pc.dcnt coupli,g cocrgy bcrw.c'l domars tn ditr rcnt trains. Thc 6cld d...

We are concerned with employing Model Order Reduction (MOR) to efficiently solve parameterized multiscale problems using the Localized Orthogonal Decomposition (LOD) method. Like many methods, LOD follows idea of separating problem into localized fine-scale subproblems and an effective coarse-scale system derived from solutions local problems. While Reduced Basis (RB) method has already been us...

An adaptive reduced basis finite element heterogeneous multiscale method (RB-FE-HMM) is proposed for elliptic problems with multiple scales. The multiscale method is based on the RB-FE-HMM introduced in [A. Abdulle and Y. Bai, J. Comput. Phys, 2012, in press]. It couples a macroscopic solver with effective data recovered from the solution of micro problems solved on sampling domains. Unlike cla...

In this work, we investigated polarization-resolved photoinduced carrier relaxation dynamics associated with charge ordering (CO) in geometrically frustrated organic conductors $\ensuremath{\theta}\text{\ensuremath{-}}{(\mathrm{BEDT}\text{\ensuremath{-}}\mathrm{TTF})}_{2}M\mathrm{Zn}{(\mathrm{SCN})}_{4}$ (M = Rb, Cs) as a function of temperature. $\ensuremath{\theta}\text{\ensuremath{-}}\mathrm...

SecA is a central component of the general secretion system that is essential for growth and virulence of bacteria. A series of fluorescein analogs were tested against ATPase activities of Escherichia coli SecA. Rose Bengal (RB) and Erythrosin B are potent inhibitors abolishing the activities of three forms of SecA ATPase with IC50 in μM range. Both inhibit SecA intrinsic ATPase with two mechan...

leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. leptin and itsreceptor (ob-r) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. the goal of this study was determination of the presence of leptin receptor mrna in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...

A reduced-order strategy based on the reduced basis (RB) method is developed for the efficient numerical solution of statistical inverse problems governed by PDEs in domains of varying shape. Usual discretization techniques are infeasible in this context, due to the prohibitive cost entailed by the repeated evaluation of PDEs and related output quantities of interest. A suitable reduced-order m...