The effects of sympathetic- and parasympathetic-nerve stimulation on the synthesis of transferrin and other serum proteins from [14C]leucine and their secretion were studied in rat liver perfused in situ. The radioactivities incorporated into perfusate transferrin, albumin and total protein increased with time during 90 min perfusion after an initial lag period of 15-30 min. The increases in th...

object: the gold standard for evaluating bone mineral density is dual energy x-ray absorptiometry (dexa).  prior studies have shown poor reliability using analog wrist x-rays in diagnosing osteoporosis. our goal was to investigate if there was improved diagnostic value to visual assessment of digital hand x-rays in osteoporosis screening. we hypothesized that similar to analog counterparts, dig...

The Semipalatinsk area is highly contaminated with radioactive fallout from 40 years of continuous nuclear testing. The biological effects on human health in this area have not been studied. Significant remaining radioactivities include long-lived radioisotopes of 238,239,400Pu, 137Cs and 90Sr. To evaluate the long-term biological effects of the radioactive fallout, the incidence of micronuclei...

We described previously a mechanistic model of whole-body protein turnover in rodents. Channeling was defined as the flow of amino acids from the extracellular compartment to aminoacyl tRNA and protein synthesis. Recycling was defined as the flow of amino acids from protein degradation to aminoacyl tRNA (protein synthesis) without mixing with the intracellular pool of amino acids. In this paper...

Dictyostelium discoideum was exposed to low levels of ~-14C]glucose at various stages during the culmination process, and seven metabolites were isolated to determine their specific radioactivities. Steady state models having 15 metabolite pools were constructed to interpret the data obtained. The models are based on certain assumptions, the flux of key reactions, and the cellular concentration...

background: wearing spectacles is the most common approach in correcting the refractive errors worldwide. due to harmful effects of overexposure to solar ultraviolet radiations, the usage of multi-layer coatings in ophthalmic lenses has recently been increased. these lenses can reduce the reflections and hence increase the transmission of visible light; they can also decrease the transmission o...

1. Nerve cell bodies were isolated in bulk from cerebral cortices of 15 day-old rabbits after intrathecal injections of [(3)H]plamitate, [(3)H]oleate or [(3)H]arachidonate and [(14)C]glycerol. 2. Nuclear, microsomal and two mitochondrial fractions were isolated from homogenates of the radioactively labelled nerve cell bodies by using differential and discontinuous-gradient centrifugation. 3. Af...