The ataxia telangiectasia mutated (ATM)-p53 pathway is a well-known main signal transduction pathway for cellular responses, which is activated by g-ray irradiation. Microarray analysis showed changes in the expressions of IFN-stimulated genes (ISG) in g-ray–irradiated Balb/cA/Atm-deficient mouse embryonic fibroblasts (MEF) (ATM-KO), indicating that another pathway for cellular responses beside...

Embryos excised from wheat (Triticum aestivum) grains following gamma-ray irradiation at different doses were analyzed on membrane permeability by electron paramagnetic resonance (EPR) technique with 4-oxo-2, 2, 6, 6-tetramethyl-1-piperidinyloxy (TEMPONE) as spin probe to acquire an EPR spectrum. The broadening agent ferricyanide added leads to changes in the high-field region of the EPR spectr...

The aim of this study was to examine the early effects of low dose (12)C(6+) irradiation or X-ray on peripheral blood lymphocytes (PBL) of patients with alimentary tract cancer and to explore mechanisms that may be involved in an antitumor immune response. We found that the percentage of T lymphocyte subsets, the mRNA expression levels of IL-2 and IFN-γ in PBL, and their protein levels in super...

Our aim was to evaluate whether repetition of C-ion (carbon ion beam) irradiation induces radioresistance as well as repeated X-ray irradiation in cancer cell lines, and to find the key molecular pathway for radioresistance by comparing radioresistant cancer cells with their parental cells. A mouse squamous cell carcinoma cell line, NR-S1, and radioresistant cancer cells, NR-S1-C30 (C30) and NR...

BACKGROUND Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized titanium peroxide nanoparticles (TiOxNPs) and investigated their efficacy as novel agents that can potently enhance the effects of radiation in the treatment of pancreatic cancer. METHODS TiOxNPs and polyacrylic acid-modif...

The effects of irradiation with 17 MeV electron beams and “‘Co y-rays on the magnetic flux of Nd-Fe-B and Sm-Co permanent magnets have been studied. At an electron dose of 2.1 X 10d3 C/cm’ (at an absorbed dose of 2.6 MGy), the magnetic flux loss of Nd-Fe-B is 9%, while the flux loss of Sm-Co is below 0.4% at a dose of 1.4 X 10B3 C/cm’. After remagnetization of the irradiated Nd-Fe-B sample the ...

Saccharomyces cerevisiae has served as a eukaryotic model in radiation biology studies of cellular responses to ionizing radiation (IR). Research in this field has thus far mainly been focused on DNA strand breaks, DNA base damage, or inhibition of protein activity. However, the effects of IR on S. cerevisiae cell membranes have barely been studied. Here, we investigated the changes in the perm...

Aqueous solutions of isovaline and its precursor molecule, 5-ethyl-5-methylhydantoin, were irradiated with ultraviolet and γ-ray photons, to evaluate their structural stability against space radiation. The degree of photolysis was measured and irradiation products were identified using chiral, reversed-phase and ion-exchange high-performance liquid chromatography. The experimental results show ...

BACKGROUND The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS We used a cell function imager to quantitatively measure the fluorescence intensity of γ-H2A.X foci in MDR (0.015 Gy/h and 0.06 Gy/h) or high-dose-rate (HDR) (54 Gy/h) γ-ray irradiated embryonic fibroblasts derived from DNA-depe...