To assess the influence of hormones on uterine infections, Escherichia coli was infused into uterine lumens of ovariectomized or adrenoovariectomized rats receiving exogenous administration of various doses of ovarian hormones. Large numbers of E. coli were recovered from the rat uterine lumens, irrespective of hormonal influences. The number of leukocytes in the uterine flushings, representing...

1. Ovariectomy-delayed blastocysts flushed from mice treated with medroxyprogesterone acetate were injected into the lumina of immature mouse uterine horns. The horns were then maintained as organ cultures for 1-3 days in media that contained either (a) ethanol or ethanol plus (6) progesterone, (c) oestradiol or (d) progesterone and oestradiol. 2. Trophoblast invasion of the uterine stroma occu...

During the growth of the pregnant uterus of inbred Balb/c mice uterine colony-stimulating factor (CSF) content increased 800-fold. This corresponded to a 75-fold increase in CSF concentration. The size of the increase was the same in the uteri of inbred Balb/c mice and the uteri of F1 hybrid C57Bl/Balb/c mice mated with F1 males. It was about four times greater in these uteri than it was in the...

The spontaneous contractions of the rabbit uterine horns and the human myometrial strips were stimulated by oxytocin and buserelin acetate in isolated preparations. Spironolactone application to these models produced inhibitory effects on the contractions. It is concluded that spironolactone has inhibitory effect on the rabbit uterine horn and the human myometrial strip contractions.

BACKGROUND Cyclooxygenase (COX)-derived prostanoids (PGE2, PGI2) are important contributors to the process of decidualization. Previous studies showed the presence of Ang-(1-7) in the primary and secondary decidualized zones of the implantation site at early pregnancy. Decreased concentrations of Ang-(1-7) were found in the decidualized uterus compared to the non-decidualized uterus of pseudopr...

Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a distinct type of proliferating cells: large epithelioid decidual cells with ro...

Globally, primary dysmenorrhoea is one of the most frequent gynaecological disorders in young women. It is associated with increased uterine tone, and exaggerated contractility of uterine smooth muscles. In many rural African communities, a number of medicinal plants, including Psidium guajava Linn. (family: Myrtaceae), are used traditionally for the management, control and/or treatment of prim...

Morphology of the uterus and mammary glands were studied in sexually matured female African giant rat. The uterus was identified as being duplex, having two separate uterine horns and two cervices. The two cervices were partially fused and separated by a mid-saggital septum. Their thick musculatures projected caudally into the vagina as the portio vaginalis uteri. The results also showed that e...

Rats of relatively low susceptibility to spontaneous carcinoma were studied. The estrone used was crystalline folliculin. Experiment 1 inv olved 12 rats, of which half were ovariectomized at the age of 58 days. All animals received daily vaginal application of a solution of estrone in corn oil from the age of 62 days until death. Hysterectomy was done on some to remove pyometra. Some were ...