1. Rat plasma was subjected at 4 degrees C to various treatments known to convert inactive renin into its active form in human plasma. 2. No statistical differences in plasma renin concentration were found when the levels after the various treatments were compared with that of untreated rat plasma. 3. It is concluded that, in contrast to human plasma, no inactive form of renin is present in rat...

Recently, immune checkpoint inhibitors, including anti-programmed cell death protein 1 (PD-1) antibodies, have dramatically changed treatment strategies for several cancers. In pharmacokinetic/pharmacodynamic studies, experiments using a variety of animal species are assumed. We identified optimal multiple reaction monitoring transitions signature candidate peptides nivolumab in human, mouse, a...

In cultures of rat marrow cells essentially all of the labeled iron which was incorporated into heme was shown to be in hemoglobin. Iron bound to rat plasma was incorporated into hemoglobin to a greater extent than was iron bound to fetal calf serum. Incorporation of iron bound to rat plasma was greater when some fetal calf serum was present than when rat plasma provided the total protein. Thes...

GIZh-290 is a new derivative of 4-phenylpyrrolidone, based on the structures racetams that combine anticonvulsant and nootropic effects. The method high-performance liquid chromatography with mass spectrometric detection was developed validated for quantitative determination potential compound in rat blood plasma. For extraction analyte, liquid-liquid diethyl ether used. its selectivity, linear...

genus rattus from the subfamily murinae has a wide geographical distribution throughout the world. three species of this genus have been reported in iran so far. they are norway or brown rat (rattus norvegicus), black rat (rattus rattus), and himalayan rat (rattus pyctoris). in order to verify the possibility of using electrophoretic patterns of special proteins, in biosystematic analysis of th...

Chinese jujube (Ziziphus jujuba Mill.) has long been widely used for human consumption and medicinal purposes in China. It has been reported to possess several vital biological activities. However, the systematic study on the chemical constituents absorbed into plasma and their metabolites is still insufficient. A high-performance liquid chromatography-photodiode array detector-electrospray ion...

Chinese jujube (Ziziphus jujuba Mill.) has long been widely used for human consumption and medicinal purposes in China. It has been reported to possess several vital biological activities. However, the systematic study on the chemical constituents absorbed into plasma and their metabolites is still insufficient. A high-performance liquid chromatography-photodiode array detector-electrospray ion...

Objective: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity.  The aim of  the present study was to examine in vitro and in vivo effects of  stevioside on rats  plasma levels of tumor necrosis factor- α (TNF-α),  interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (P...

Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...