The review examines the historical aspects of hippocampus nomenclature. Its anatomical study began by ancient Greeks, who called unusual–looking structure a “ram’s horn” – cornu ammonis. term “hippocampus” (ancient Greek: ἱππόκαμπος, from ἵππος, “horse” and κάμπος, “sea monster”, or “sea-horse”) was first introduced in sixteenth century anatomist J.C. Arantius. “hippocampal formation” is curren...

traumatic brain injury (tbi) is one the most common cause of disability between young adults. these people have been socially isolated during post-surgery traumatic brain injury. in this study we investigated the effect of social isolation on the structural deficits after tbi in the young rats. young rats were divided into control group with social interaction, sham group with social isolation ...

BACKGROUND/AIMS To investigate the protective effect of SGK1 (serum- and glucocorticoid-inducible protein kinase 1) in rat hippocampal neurons in vitro and in vivo following ischemia reperfusion (I/R). METHODS Isolated rat hippocampal neurons were subjected to 2 h of oxygen and glucose deprivation (OGD) then returned to normoxic conditions for 10, 30 or 60 min. Cell apoptosis and protein expr...

The ring rate maps of hippocampal place cells recorded in a freely moving rat are viewed as a set of approximate radial basis functions over the (2-D) environment of the rat. It is proposed that these ring elds are constructed during exploration from `sensory inputs' (tuning curve responses to the distance of cues from the rat) and used by cells downstream to construct ring rate maps that appro...

Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region of a rat model of AD. Methods: In the current experimental study, adult male Wistar rats were randomly divided into four groups: Nucleus Basal...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...

Hippocampal spatial view cells found in primates respond to a region of visual space being looked at, relatively independently of where the monkey is located. Rat place cells have responses which depend on where the rat is located. We investigate the hypothesis that in both types of animal, hippocampal cells respond to a combination of visual cues in the correct spatial relation to each other. ...