Aim: Pedobarographic analysis may be employed to quantify foot function, however, the value of pedobarographic analysis as a diagnostic tool for the screening of recently diagnosed Rheumatoid Arthritis (RA) patients remains uncertain. The aim of this systematic review was to: a) assess the different instruments used to analyse plantar pressure; b) to report on the technical considerations assoc...

OBJECTIVE To assess the impact of certolizumab pegol (CZP), a novel PEGylated anti-tumor necrosis factor, in combination with methotrexate (MTX) on productivity outside and within the home, and on participation in family, social, and leisure activities in adult patients with rheumatoid arthritis (RA). METHODS The efficacy and safety of CZP (200 mg and 400 mg) plus MTX were assessed in 2 phase...

A bst ract A computational model of emotion must explain both the rapid dynamics of some emotional reactions as well as the slower responses that follow deliberation. This is often addressed by positing multiple levels of appraisal processes such as fast pattern directed vs. slower deliberative appraisals. In our view, this confuses appraisal with inference. Rather, we argue for a single and au...

This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of certolizumab pegol (CZP) for adults with active rheumatoid arthritis (RA) that have not responded adequately to treatment with conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX), in accordance with the licensed indication, based...

This paper is a survey of recent results concerning connections between relation algebras (RA), cylindric algebras (CA) and polyadic equality algebras (PEA). We describe exactly which subsets of the standard axioms for RA are needed for axiomatizing RA over the RA-reducts of CA3’s, and we do the same for the class SA of semi-associative relation algebras. We also characterize the class of RA-re...

OBJECTIVE To determine the contribution of human parvovirus B19 infection in explaining the incidence of early inflammatory polyarthritis (IP) in a population. SETTING The Norfolk Arthritis Register (NOAR) is a community-based programme aiming to ascertain all new cases of IP arising in a population that lead to attendance at primary care. SUBJECTS 147 newly ascertained subjects with IP wit...