All studies were categorised according to the strength of the evidence based on the following revised classification system. Level I Evidence obtained from a systematic review of all relevant randomised controlled trials. Level II Evidence obtained from at least one properly designed randomised controlled trial. Level III.1 Evidence obtained from well designed pseudo-randomised controlled trial...

All studies were categorised according to the strength of the evidence based on the following revised classification system. Level I Evidence obtained from a systematic review of all relevant randomised controlled trials. Level II Evidence obtained from at least one properly designed randomised controlled trial. Level III.1 Evidence obtained from well designed pseudo-randomised controlled trial...

BACKGROUND There is a growing interest in using cognitive-behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems. AIMS To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious. METHOD Using a randomised assessor-blind trial, 52 individuals with Asperger s...

BACKGROUND A growing body of observational evidence suggests that nutritional and physical activity interventions are associated with beneficial outcomes for men with prostate cancer, including brisk walking, lycopene intake, increased fruit and vegetable intake and reduced dairy consumption. However, randomised controlled trial data are limited. The 'Prostate Cancer: Evidence of Exercise and N...

OBJECTIVE To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on all cause mortality and cardiovascular mortality, non-fatal myocardial infarction, microvascular complications, and severe hypoglycaemia in patients with type 2 diabetes. DESIGN Systematic review with meta-analyses and trial sequential analyses of randomised trials. DATA SOURCES ...

OBJECTIVES Glandular fever is associated with an approximate fivefold increase in fatigue at 6 months. Reduced levels of fitness and illness beliefs may be important predictors of fatigue following glandular fever. We therefore developed a brief psycho-educational intervention aimed at improving recovery from infectious mononucleosis, and piloted a randomised controlled trial to evaluate the in...