Abstract INTRODUCTION The optimal dose for single-fraction radiosurgery (SRS) small brain metastases (BM) (< 2 cm) has not been established considerable variability in selection. METHODS Consecutive patients diagnosed with intact BM < cm maximum dimension treated SRS to prescription doses of 24, 22, or 20 Gy on the Gamma Knife® between 3/2019-1/2021 were reviewed. Institutional do...

Abstract PURPOSE To report preliminary results on outcomes of patients with lower grade gliomas (LGG) treated proton therapy. METHODS Patients II or IDH mutant III glioma and indications for radiation therapy were enrolled in a prospective single arm trial (PRT), receiving dose 54 Gy(RBE) 59.4 Gy(RBE), respectively. Comprehensive baseline regular post-treatment evaluations neuroendocrine functi...

Abstract INTRODUCTION Patients with multiple sclerosis (MS) may be at higher risk of brain tumors (Khalil 2012, London 2020, etc.). However, MS patients have been reported to adverse effects from radiotherapy, a mainstay CNS treatment. In the last ten years, radiation techniques improved. We submit case report an patient demyelinating lesions shortly after therapy for astrocytoma and review lit...

Abstract BACKGROUND No consensus exists on the optimal irradiation volume/dose for patients with metastatic CNS germinoma. We reviewed literature a potential association between different treatment modalities and survival. METHODS searched PubMed studies primary germinoma including detailed survival outcome data. used Kaplan-Meier method to estimate event-free (EFS) rates log-rank test comparis...

Abstract BACKGROUND CNS injury following brain-directed radiotherapy (RT) is common and may mimic disease progression. Dosimetric advantages of protons (PRT) over photons (XRT) minimize radiation to healthy brain, potentially limiting radiotoxic sequelae. We characterized radiotoxicity i.e., radiation-induced leukoencephalopathy (RIL), brain tissue necrosis (TN), cerebral microbleeds (CMB), dur...

Abstract INTRODUCTION Large brain metastases (BM) are associated with poor local control single-fraction radiosurgery (SRS) alone. We sought to compare outcomes various alternative management strategies assess disease rates. METHODS Consecutive patients diagnosed BM ≥ 2 cm in maximum diameter between 3/2019-2/2021 and treated at a single tertiary institution were included. Primary endpoints inc...

Abstract Introduction Identifying, segmenting, measuring, and following multiple brain metastases treated with radiosurgery can be time consuming error prone. Machine learning has shown promise for automated detection segmentation. Recently, a U-Net inspired model combining volume aware loss functions sampling methods was trained in an industrial-academic partnership. A total of 530 clinically ...

The empirical or semi-empirical model is widely used for vehicle simulation because of its high accuracy but relies on massive experimental data tire force and moment. Therefore, mechanical prediction great significance to improve modeling efficiency reduce costs. Typical methods models based normalization presented by Pacejka Radt assume that different loads could be close one normalized curve...