نتایج جستجو برای: radioprotector

تعداد نتایج: 210  

2008
J. Mata K. Sheng P. Read K. Ruppert K. Hagspiel T. Altes W. Tobias G. Cates J. Brookeman

control group (radiation only). A & B: CT scans with radiation treatment planning superimposed. Area in red received full radiation dose (3x11Gy). All animals received radiation in same location. C & D: CT scans at 8 weeks post radiation. While lung in C has homogeneous tissue density, the lung in D shows an area of hypodensity that correlates with the irradiated area (oval and arrow). E & F: c...

2017
Amrita K Cheema Khyati Y Mehta Oluseyi O Fatanmi Stephen Y Wise Charles P Hinzman Josh Wolff Vijay K Singh

The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiati...

Journal: :iranian journal of radiation research 0
l. ramachandran amala cancer research centre, thrissur 680555, kerala, india c.k.k. nair pushpagiri institute of medical sciences and research centre, thiruvalla 689101, kerala, india

background: ionizing radiation induces the production of reactive oxygen species (ros), which play an important causative role in cell death. wholebody exposure of mice to gamma radiation leads to diminution of tissue antioxidant defense systems increases the peroxidative damage to membrane lipids and damages the haematopoietic and gastrointestinal systems. tempol (tpl), a cell membranepermeabl...

Journal: :Cancer research 2004
Roger F Martin Sam Broadhurst Monica E Reum Christopher J Squire George R Clark Pavel N Lobachevsky Jonathan M White Chris Clark Denise Sy Melanie Spotheim-Maurizot David P Kelly

New analogues of the minor groove binding ligand Hoechst 33342 have been investigated in an attempt to improve radioprotective activity. The synthesis, DNA binding, and in vitro radioprotective properties of methylproamine, the most potent derivative, are reported. Experiments with V79 cells have shown that methylproamine is approximately 100-fold more potent than the classical aminothiol radio...

2011
A. Kunwar

Exposure of living organisms to ionizing radiation can cause health hazards and radioprotectors are employed to minimize such unwanted effects. Over the years a number of sulfhydryl compounds have been examined for radioprotection and only one agent, amifostine, is approved in the clinic. Selenium, a higher analogue of sulfur, is a micronutrient and a constituent of redox enzymes like glutathio...

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