A noninvasive method of detecting exposure of phosphatidylserine (PS) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of apoptosis related pathologies. The most studied imaging agent for apoptosis is Annexin V so far. Because of limitations of Annexin V other agents have been introduced such as small peptides and molecules. Radiopept...

The integrin family comprises 24 transmembrane receptors, each a heterodimeric combination of one of 18α and one of 8β subunits. Their main function is to integrate the cell adhesion and interaction with the extracellular microenvironment with the intracellular signaling and cytoskeletal rearrangement through transmitting signals across the cell membrane upon ligand binding. Integrin αvβ3 is a ...

UNLABELLED Nephrotoxicity due to renal reabsorption of radiolabeled peptides limits the tumor dose in peptide receptor radiotherapy (PRRT). Therefore, we evaluated the ability of several agents to inhibit the renal accumulation of different radiopeptides. METHODS Male Wistar rats (4 per group) were injected intravenously with 1 MBq of (111)In-labeled octreotide (OCT), minigastrin (MG), bombes...

Cancer is one of the main causes of morbidity and mortality worldwide. The most frequent types of this disorder are lung, breast, colorectal, prostate, stomach and liver cancers. In 2012, approximately 14.1 million new cases of the disease were registered, resulting in about 8.2 million of deaths [1]. Most of these deaths could be avoided if an early diagnosis is achieved. As a result, many eff...

UNLABELLED In most types of peptide receptor radionuclide therapy, the maximum activity dose that can be administered is limited by high and persistent renal retention of the radiolabeled peptides, which is, at least partly, mediated by the megalin receptor. Several agents that interfere with renal reabsorption of radiolabeled peptides have been identified (e.g., lysine, arginine, succinylated ...

The specificity of a diagnostic assay depends upon the purity biomolecules used as probe. To get specific and accurate information disease, use synthetic peptides in diagnostics have increased last few decades, because their high profile ability to modified chemically. discovered peptide probes are either imaging or non-imaging diagnostics. In diagnostics, techniques such Enzyme-Linked Immunoso...

Somatostatin analogues (SSA), both radiolabeled and unlabeled play an important role in the management of carcinoid tumors. They are often administered in parallel, the unlabeled analogue for treating the carcinoid tumors' symptoms and the radiolabeled one for imaging tumors foci. There is a debate about when is the optimum time for a somatostatin receptor scintigraphy during treatment. Opinion...